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modifier

modifier

1 7.9
A gene that changes the effect of another gene
  • noun
  • /ˈmɒdɪfaɪər/
  • Specialized
translation icon : gen modificador
  • The study identified several genetic modifiers that influence how patients respond to treatment.
  • effect modifier
  • epigenetic modifiers
  • potential modifier

Examples

  • In genetics, a modifier can change the way a particular trait is expressed in an organism.

  • Researchers are exploring how environmental factors can act as modifiers of gene expression.

  • Age was an effect modifier.

    Academic text (2015)
  • Age was an effect modifier only in the model with TRTCENTER and LDST.

    Academic text (2012)
  • We studied the role of variables as potential confounders/modifiers, but only age was statistically significant.

    Academic text (2015)
  • The CHADS2-VASc score has been proposed to complement the CHADS2 score by the inclusion of additional stroke risk modifier factors.

    Academic text (2011)
  • In the process of interactions, MYOC is a potential modifier gene (205).

    Academic text (2018)
  • The relative effects of DMTs were implemented as modifiers of the modeled clinical course of MS.

    Academic text (2016)
  • However, biologic response modifiers are associated with a higher risk of serious infections in patients with other autoimmune diseases.

    Academic text (2017)
  • The evidence regarding all available biologic response modifiers has not been systematically appraised and included in recommendations of clinical guidelines.

    Academic text (2017)

Synonyms

suppressor
vsmodifier
  • Specialized
4 8.8

A gene that reduces the effects of another gene, often a harmful change

alters effects broadly rather than only hiding visible traits
modifier gene
vsmodifier
  • Specialized
7.2

A gene that changes how another gene affects a trait

is the shorter label for the same concept
epistatic gene
vsmodifier
  • Specialized
9.6

A gene that hides the effect of another gene so a trait does not appear

alters effects more generally rather than only masking at another locus
suppresser
vsmodifier
  • Specialized
8.8

A gene that stops another gene from showing its effect

has identical meaning but uses the other standard spelling

Compounds

dangling modifier
  • Specialized
8.3

A word or phrase in a sentence placed so it seems to describe the wrong thing and confuses the reader

modifier gene
  • Specialized
7.2

A gene that changes how another gene affects a trait

misplaced modifier
  • Specialized
8.4

A word or phrase placed so it seems to describe the wrong part of a sentence and confuses the meaning

Surface Forms

modifier singular
modifiers plural

Morphology

modifier = modify (transparent) = modify + er

The noun is formed by the productive agent/instrument suffix '-er' added to the verb 'modify', yielding 'one or something that modifies'.

Etymology

Modifier comes from the root mod meaning 'measure' or 'way', and is related to the verb modify 'to make change'. So in genetics a modifier is something that changes the effect or strength of another gene.