Skip to main content
antagonist

antagonist

4 7.3
A substance that blocks or reduces another substance's effect, for example a medicine
  • noun
  • /ænˈtæɡənɪst/
  • Specialized
translation icon : antagonista
  • Myostatin antagonists may emerge as a novel intervention to reduce sarcopenia and frailty.
  • calcium antagonists
  • receptor antagonists
  • leukotriene antagonists

And DHEA is known to be a potent antagonist of the GABA system.

Autoplay Next

Examples

  • And we also know that it's an NMDA receptor antagonist or blocker.

  • Administration of competitive CRF receptor antagonists generally has the opposite effects.

    Academic text (2009)
  • And DHEA is known to be a potent antagonist of the GABA system.

  • At this stage, however, an aldosterone antagonist is often introduced, such as spironolactone or eplerenone.

    Academic text (2011)
  • A longer-acting narcotic antagonist, naltrexone, was approved for use in 1984.

    Academic text (1993)
  • Biological plausibility: Metoclopramide has centrally nervous system actions and is an antagonist of dopamine.

    Academic text (2007)
  • Incubation of the basophils with naloxone, another opioid antagonist, prevented this effect.

    Academic text (1996)
  • Availability of more potent P2Y12 antagonists may render this a moot question.

    Academic text (2015)
  • In adults, apixaban reduces bleeding and all-cause mortality compared with vitamin K antagonists.

    Academic text (2015)
  • In treating addiction, naltrexone acts as an antagonist by blocking the effects of opioids.

Synonyms

antidote
vsantagonist
  • Specialized
171 5.3

A medicine or substance that stops the harm caused by a poison

works mainly on drugs to block or reduce physiological effects
inhibitor
vsantagonist
  • Specialized
46 6.0

A substance that slows down and can stop chemical reactions in the body or in a lab

acts to reduce or block another substance's physiological effect rather than general processes
blocker
vsantagonist
  • Specialized
19 6.0

A medicine that stops a chemical in the body from working to treat health problems

targets the effect of another substance rather than general process blocking
blocking agent
vsantagonist
  • Specialized
1 5.8

A medicine that stops or reduces a body process, for example a hormone action

acts specifically to reduce or block the effect of another substance
narcotic antagonist
vsantagonist
  • Specialized
6.1

A drug that stops the effects of strong pain medicines and helps breathing

is used more broadly to block or reduce other drug effects

Antonyms

agonist
  • Specialized
2 7.9

A drug or chemical that binds to a cell receptor and causes a response

Compounds

estrogen antagonist
  • Specialized
6.7

A medicine that stops estrogen from working used to treat some breast cancers

narcotic antagonist
  • Specialized
6.1

A drug that stops the effects of strong pain medicines and helps breathing

strong antagonist
  • Literature
5.1

A powerful character who opposes the hero and creates major conflict

ultimate antagonist
  • Literature
7.9

The main enemy at the end of a story who the heroes must defeat

How Blocking

antagonist
  • Specialized
4 7.3
agonist
  • Specialized
2 7.9

Surface Forms

antagonist singular
antagonists plural

Morphology

antagonist = agonist (opaque) = anti + agonist

This technical pharmacological sense is built on the anti- plus agonist pattern, but the meaning is specialized and not easily inferred by average learners.

Etymology

Antagonist comes from the Greek parts anti- 'against' and agon 'contest'. In medicine an antagonist is a drug that works 'against' another chemical and so it blocks or reduces that chemical's effect.