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synthetase

synthetase

1 8.4
A protein that joins two molecules using energy from ATP
  • noun
  • /sɪnˈθeɪteɪs/
  • Specialized
: sintetasa
  • In the second step, glutathione synthetase (GS) adds glycine to glutamyl-cysteine to form glutathione.
  • glutamine synthetase
  • synthetase gene

Examples

  • Ammonium can be incorporated into glutamate via glutamine synthetase (GS) to form glutamine (Figure 2).

    Academic text (1993)
  • But there's amino acid tRNA synthetase and the tRNA for this alkyne.

  • When cells are exposed to growth in medium without glutamine, the glutamine synthetase gene expression is increased.

    Academic text (2017)
  • Well, your amino acid tRNA synthetases are not AAA plus ATPAS.

  • (n9) Moreover, because they are both prostaglandin synthetase inhibitors, ibuprofen and naproxen could, in theory, cause premature closure of the ductus arteriosus.

    Academic text (2003)
  • The enzyme synthetase helps in forming complex molecules by utilizing energy from ATP.

  • Researchers studied the activity of synthetase to understand its role in metabolic pathways.

  • The plant produces a specific type of synthetase that synthesizes essential amino acids.

Synonyms

ligase
vssynthetase
  • Specialized
1 8.4

A protein that joins two pieces of DNA or other molecules together

requires ATP energy for its action rather than being defined by context

Surface Forms

synthetase singular
synthetases plural

Morphology

synthetase = synthesis (semi-transparent) = synthet + ase

The root relates to 'synthesis' (making/combining) and '-ase' denotes an enzyme, but understanding requires knowledge of the specialized suffix '-ase' used in biochemistry.

Etymology

Synthetase comes from synthesis, which means 'to put together', and the enzyme ending -ase, which means 'enzyme'. So a synthetase is an enzyme that 'puts things together', linking molecules using energy.