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proteasome

proteasome

1 9.9
A cell machine that breaks down damaged or unneeded proteins into small parts
  • noun
  • /ˈproʊtiəˌsoʊm/
  • Specialized
translation icon : proteasoma
  • For example, melatonin, by inhibiting the proteasome, can interfere with CRY/PER degradation (Vriend and Reiter, 2014, 2015), thus prolonging the period of the cycle.
  • protein through a proteasome

And in fact, one of the machineries that gets rid of these defective proteins is called a proteasome.

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Examples

  • Finally, nucleotide metabolism and cell death-related pathways were overall induced in CHs, with proteasome (the protein-destroying apparatus) being the most induced pathway (Table 3).

    Academic text (2017)
  • Another example involves the proteasome, which we'll hear about in the second-half of the course.

  • She was switched to bortezomib, a proteasome inhibitor, but her disease continued to progress.

    Academic text (2010)
  • Possible interaction of HMB with the ubiquitin-proteasome proteolysis-dependent pathway

    Blog text (23)
  • Mechanism dissection indicated that Niclosamide could degrade the ARv7 protein through a proteasome-dependent pathway.

    Academic text (2017)
  • Evidence from cachectic cancer studies suggests that HMB may inhibit the ubiquitin-proteasome proteolytic pathway responsible for the specific degradation of intracellular proteins.

    Blog text (23)
  • The proteasome is essential for breaking down damaged proteins in the cell.

  • Scientists study the proteasome to understand how it regulates protein degradation.

  • Research shows that the proteasome plays a critical role in maintaining cellular health.

Synonyms

protease
vsproteasome
  • Specialized
7 7.7

An enzyme that breaks proteins into smaller pieces

is a large multi protein cellular complex that breaks damaged or unneeded proteins
proteolytic enzyme
vsproteasome
  • Specialized
1 4.4

A substance that breaks proteins into smaller parts living things can use

is a large multi protein cellular complex that breaks damaged or unneeded proteins
proteinase
vsproteasome
  • Specialized
1 7.2

A substance in living things that breaks proteins into smaller parts

is a large multi protein cellular complex that breaks damaged or unneeded proteins
cathepsin
vsproteasome
  • Specialized
1 9.3

An enzyme in animal cells that breaks down proteins inside small parts of the cell that digest things

is a large multi protein cellular complex that breaks damaged or unneeded proteins
peptidase
vsproteasome
  • Specialized
8.8

An enzyme that breaks proteins into smaller pieces called peptides and amino acids

is a large multi protein cellular complex that breaks damaged or unneeded proteins
carboxypeptidase
vsproteasome
  • Specialized
9.9

An enzyme that removes amino acids from the end of a protein chain

is a large multi protein cellular complex that breaks damaged or unneeded proteins

Surface Forms

proteasome singular
proteasomes plural

Morphology

proteasome = protease (semi-transparent) = proteas + some

Formed from the enzyme name 'protease' plus the technical combining element '-some' (as in ribosome); the relation is clear in molecular-biology contexts but '-some' is a specialised morpheme unfamiliar to average learners.

Etymology

Proteasome joins protein and -some from Greek soma meaning 'body', like in ribosome and lysosome. So, a proteasome is a 'body' in the cell that breaks down not needed or damaged proteins.