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protease

protease

7 7.7
An enzyme that breaks proteins into smaller pieces
  • noun
  • /ˈproʊtiˌeɪs/
  • Specialized
translation icon : proteasa
  • By the mid-1990s, combinations of antiretroviral therapy, including protease inhibitors, were shown to significantly delay the onset of AIDS.
  • protease inhibitor
  • protease activity
  • protease enzyme

Paxlovid binds to an enzyme called protease to stop the virus from replicating itself.

Examples

  • The beans contain proteins, such as trypsin inhibitor, which suppress the action of proteases in the human digestive system.

    Academic text (2001)
  • Proteins in the cell are broken down by a specific kind of protease that activates during metabolism.

  • Development of resistance has been seen with these agents, including cross-resistance to other protease inhibitors.

    Academic text (2000)
  • The balance of proteases and antiproteases is essential for normal lung function.

    Academic text (2007)
  • The integrity of the gel is severely impaired by the activity of protease enzymes during the heating step.

    Academic text (1993)
  • Paxlovid binds to an enzyme called protease to stop the virus from replicating itself.

  • Inhibition of PR3, using serine protease inhibitors, is therefore an attractive potential target.

    Blog text (17)
  • They secrete proteases that remodel the tissue that would also help with regeneration and repair.

  • Various investigators have studied the protease-antiprotease balance in the development of different respiratory conditions like COPD, emphysema, bronchiectasis, and bronchial asthma.

    Academic text (2007)
  • The research team studied how the protease breaks down food proteins in the digestive system.

Synonyms

proteolytic enzyme
vsprotease
  • Specialized
1 4.4

A substance that breaks proteins into smaller parts living things can use

has identical meaning but uses the shorter, common form
proteinase
vsprotease
  • Specialized
1 7.2

A substance in living things that breaks proteins into smaller parts

has identical meaning but appears as an alternative technical term
peptidase
vsprotease
  • Specialized
8.8

An enzyme that breaks proteins into smaller pieces called peptides and amino acids

shares core meaning but highlights peptide formation rather than general breakdown

Compounds

protease inhibitor
  • Specialized
5 5.3

A medicine that stops enzymes from breaking proteins and treats HIV

Surface Forms

protease singular
proteases plural

Morphology

protease = protein (semi-transparent) = prote + ase

Formed from the combining form 'prote-' (protein) plus the technical enzyme suffix '-ase'; the connection to 'protein' is clear but '-ase' is specialized and may be unknown to average learners.

Etymology

Protease comes from the common word protein and the ending -ase, which shows that the word is an enzyme, and protein comes from the Greek root protos, meaning 'first'. So, a protease is an enzyme that breaks down protein into smaller parts.