nucleosome
1
8.9
- noun
- /ˈnjuːklɪoʊˌsoʊm/
- Specialized
- The high, round features are nucleosomes, each connected to adjacent ones by a segment of a double-stranded DNA molecule.
- nucleosome occupancy
- fragile nucleosomes
Examples
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As an alternative strategy, chemical mapping of histone H4 was used to directly map nucleosome occupancy, which confirmed the presence of fragile nucleosomes.
Academic text (2018) -
What percentage of random DNA would bind at least one protein enough to disrupt nucleosome packaging?
Blog text (18) -
They look more like beads on a string, DNA wrapped around each histone protein to form those nucleosome structures.
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Indeed, nucleosome levels measured by chemical mapping appear to correlate with the degree of pausing, opposing the interpretation of early studies using MNase.
Academic text (2018) -
As an alternative strategy, chemical mapping of histone H4 was used to directly map nucleosome occupancy, which confirmed the presence of fragile nucleosomes.
Academic text (2018) -
However, the exact content and conformation of the nucleosomes around promoters, as well as their interplay with the dynamics of pausing, remain to be fully examined.
Academic text (2018) -
The nucleosome is a core component of chromatin, helping to package DNA by wrapping it around histone proteins.
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DNA is organized into nucleosomes, which are structural units that allow for efficient storage of genetic material.
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In the cell nucleus, the nucleosome plays a crucial role in determining how DNA is accessed and read.
Surface Forms
Morphology
nucleosome = nucleus (opaque) = nucleo + some
Although the form is nucle- (nucleus) + the combining element -some ('body'), the specific technical meaning (the unit of DNA wrapped around histones) is specialized and not predictable for an average learner.
Etymology
Nucleosome comes from the Latin nucleus, meaning 'little kernel' or 'center', plus the ending -some like in chromosome meaning 'body' or 'part'. Think of a nucleosome as a tiny 'body' or bead inside the cell nucleus where DNA is wrapped like thread, so the name explains why nucleosomes are the small units that pack and organize DNA.