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nucleoside

nucleoside

1 8.9
A part of DNA or RNA made of a base joined to a sugar without a phosphate group
  • noun
  • /ˈnjuːklɪˌsaɪd/
  • Specialized
translation icon : nucleósido
  • Ribavirin is a nucleoside that plays a role in the treatment of certain viral infections.
  • nucleoside analogue
  • nucleoside inhibitors
  • nucleoside reverse

Examples

  • Nucleoside analogues are promising because they complement drugs which modify the immune system.

    Academic text (1994)
  • Ribavirin is a nucleoside with an unknown mechanism of action.

    Academic text (2007)
  • So I'm going to describe to you what are known as nucleoside analogues.

  • Lamivudine, the newest nucleoside analogue to be released, may be especially useful in this respect.

    Academic text (2000)
  • Telbivudine is a synthetic thymidine nucleoside analogue with activity against HBV.

    Blog text (2)
  • However, all nucleoside reverse transcriptase inhibitors carry the risk of lactic acidosis and severe hepatomegaly.

    Academic text (2005)
  • Viral resistance to the nucleoside inhibitors of reverse transcriptase may result from multiple drug-resistant strains and can involve at least five different mutations.

    Academic text (2000)
  • Use of antiretroviral therapy in the cohort began in 1987, and by 1991, nearly 50% of the seropositive cohort was on single or combination nucleoside therapy.

    Academic text (2002)
  • Lamivudine, the first nucleoside analogue inhibitor to be approved for the treatment of CHB, has long been used for both HIV and HBV infection during pregnancy and has displayed reliable prevention effects.

    Blog text (2)
  • As an orally bioavailable L-nucleoside analogue with potent activity against HBV, telbivudine has shown no effects on human nucleotides and DNA synthesis.

    Blog text (2)

Compounds

A drug that stops HIV changing its genetic material and is used with other medicines

An HIV drug that joins viral DNA and stops the enzyme that copies the virus

Surface Forms

nucleoside singular
nucleosides plural

Morphology

nucleoside = nucleus (opaque) = nucleo + oside

Formation involves the combining form 'nucleo-' and the specialized chemical suffix '-oside' (not the common word 'side'), so ordinary learners cannot derive the specific biochemical meaning.

Etymology

Nucleoside comes from nucle-, the same root as nucleus meaning 'core' or 'kernel', plus the part -oside, which is used in words for sugar compounds. So a nucleoside is like a 'core' base joined to a sugar, which explains why it is a base plus sugar but has no phosphate group.