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noninferiority

noninferiority

1 9.1
A state of not being worse than another thing in tests, for example a new medicine
  • noun
  • /ˌnɒnˌɪn.fɪəˈrɪə.ti/
  • Specialized
: no inferioridad
  • The mean decrease in HbA1c levels was 0.83% for both groups, thereby illustrating the noninferiority of Gla-300 for glycemic control.
  • noninferiority trial
  • noninferiority margin
  • criteria for noninferiority

Examples

  • Overall, the trial by Bernard and colleagues provides strong evidence for the noninferiority of 6 weeks of antibiotics compared with 12 weeks for PVO.

    Academic text (2015)
  • All studies were powered to detect differences between Gla-300 and the comparator Gla-100 or to demonstrate the noninferiority of Gla-300 to Gla-100.

    Academic text (2017)
  • Another report described the noninferiority of evening administration of LT4, compared with that half an hour before breakfast, in drug-naive patients.

    Academic text (2016)
  • With an estimated treatment difference of 0.08%, the noninferiority of insulin degludec was confirmed.

    Academic text (2017)
  • The mean difference of 0.01% between the treatment arms met predefined criteria, thus establishing the noninferiority of Gla-300.

    Academic text (2017)
  • The BEGIN: Flex trial was designed to test the noninferiority of insulin degludec given at forced-flex intervals of 8 to 40 hours versus Gla-100 given once daily at the evening meal.

    Academic text (2017)
  • The study confirmed the noninferiority of the new treatment compared to standard care in terms of patient outcomes.

  • Evidence from various trials supports the noninferiority of the shorter antibiotic course when compared to the traditional longer regimen.

  • Clinical data showed the noninferiority of the drug against its competitor, making it a viable option for treatment.

Antonyms

19 5.1

A state of being lower than others in ability, status or value

How Inferior

inferiority
19 5.1
noninferiority
  • Specialized
1 9.1
superiority
61 5.5

Surface Forms

Morphology

noninferiority = inferiority (semi-transparent) = non + inferior + ity

The prefix 'non-' straightforwardly negates 'inferiority', but the combined term commonly has a specialized statistical/clinical meaning that goes beyond the literal negation.

Etymology

The word noninferiority starts with non- meaning 'not' and the part inferior meaning 'lower' or 'worse', so it literally means 'not lower'. That's why in medicine a noninferiority study is used to show a new treatment is 'not worse' than the standard treatment.