monogenic disease
- noun
- /ˌmɒnəˈdʒɛnɪk dɪˈziːz/
- Specialized
:
enfermedad monogénica
- Cystic fibrosis is considered a monogenic disease because it results from a mutation in a single gene.
We characterize as monogenic diseases, diseases that until yesterday we thought were acquired diseases.
- We characterize as monogenic diseases, diseases that until yesterday we thought were acquired diseases.
Examples
-
Glaucoma is a complex disease, which may be a polygenic disease rather than a monogenic disease.
Academic text (2018) -
We characterize as monogenic diseases, diseases that until yesterday we thought were acquired diseases.
-
Scientists are studying mutations that cause monogenic diseases to develop targeted treatments.
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Understanding the genetic basis of monogenic diseases can lead to improved diagnostic methods.
Synonyms
12
3.5
A health problem caused by a change in a person's genes that can be passed from parents
9
4.2
A health problem caused by changes in a person's genes that parents pass on
6
4.4
A health problem from a change in someone's genes often passed from parents
3
4.6
A change in a person's genes that causes a disease
2
3.0
A disease passed from parents to their children through genes
1
3.9
A disease passed from parents to children through genes
1
4.0
A health problem parents can pass to their children through genes
1
4.2
A disease parents pass to their children in their genes
A disease that happens when one gene changes and parents pass that change to their child
Antonyms
- Specialized
A disease passed from parents caused by several genes acting together
How Polygenic
- Specialized
- Specialized
Surface Forms
Morphology
The meaning is directly and compositionally derivable from 'monogenic' (relating to a single gene) + 'disease' (a medical condition): it denotes a disease caused by a single gene. This follows straightforward semantic composition and has clear cross-linguistic parallels (e.g., 'enfermedad monogénica'/'maladie monogénique'), so a learner who knows the constituents will understand it.
Etymology
Monogenic disease comes from old Greek parts: mono- meaning 'one' and -genic meaning 'caused by a gene'. So it literally says a disease caused by a single gene, which is why it means a condition that comes from a change in one gene.