🧬 To fold wrongly 🧬 Wrong folding

to misfold

1 7.9

To take the wrong shape, for example in a protein or material

verb
/ˌmɪsˈfoʊld/

Specialized

: mal plegar

When proteins misfold, they can accumulate and form harmful aggregates that disrupt cellular functions.
misfolded proteins
misfolded prion

PS Heat shock proteins are a protective mechanism in your brain and body to rescue proteins that would otherwise misfold.

Examples

Misfolding in proteins can lead to severe neurological disorders as they no longer misfold properly.
What if these mutant proteins misfold so they can't form their correct, their correct fold and fold is important for function.
But what does that really mean in the context of misfolding protein misfolding diseases?
But so when those proteins become damaged, they misfold and they don't get degraded properly.
"Creeping" sickness was caused by prions, misfolded proteins that directed normal ones to mimic their structure and accumulate in the motor neurons.

Fiction book (1998)
Accumulation of misfolded MYOC proteins decreases AH outflow, and that influences IOP regulation; however, its mechanism is unclear (74).

Academic text (2018)
Research has shown that certain environmental factors can cause proteins to misfold, resulting in debilitating diseases.

How Folded

to refold

Specialized

1 8.2

to misfold

Specialized

1 7.9

to denature

Specialized

2 7.4

Surface Forms

misfold infinitive

misfolded past

misfolded past participle

misfolding present participle

misfolds third person singular

Morphology

misfold = fold (transparent) = mis + fold

Standard productive prefixation: 'mis-' (incorrectly) + 'fold' yields the verb meaning 'to fold incorrectly'.

Etymology

Misfold combines mis- 'wrong' and fold 'to bend' or 'shape', so to misfold is to 'fold wrongly' or not take the right shape. That's why when proteins misfold they often lose their normal function and can cause disease.