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Glite Dictionary
🧬 To fold wrongly 🧬 Wrong folding
misfold

misfold

1 9.3
A wrong shape in a protein or material that can make it stop working
  • noun
  • /ˈmɪsˌfoʊld/
  • Specialized
: mal plegado
  • There are some human diseases that are a result of misfolded or aggregated proteins.

So my speculation is that misfolding of these proteins is an early test for failure.

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Examples

  • There are accumulations of proteins that are misfolded and potentially aggregate and those two contribute to disease and contribute to inflammation.

  • So this machinery is very important to get rid of misfolded or aggregated proteins to destroy them.

  • You know, the production of, of misfolded proteins or damaged proteins.

  • So they, these heat shock proteins take the misfolded protein, they send it to the lysosome.

  • Then we add that to this culture, the aggregate of a misfolded Tau in red.

  • And it might be more inclined, A misfolded protein to aggregate and form plaques now in the brain.

  • In Alzheimer's disease, the buildup of misfolded proteins can disrupt normal brain function.

  • Research shows that a misfolded protein can lead to serious health conditions.

  • Scientists study the effects of misfolded proteins on cellular health and disease progression.

Surface Forms

misfold singular
misfolds plural

Etymology

Misfold comes from the prefix mis- meaning 'wrong' and the word fold meaning 'to bend' or 'shape', so a misfold is a 'wrong fold'. A misfold in a protein or material can make it stop working properly or weaken the whole structure.