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lactamase

lactamase

1 8.0
A protein some bacteria make that destroys penicillin and similar antibiotics
  • noun
  • /ˈlæk.təˌmeɪs/
  • Specialized
translation icon : lactamasa
  • Repeated exposure to this drug class has evolved a genetic variation, which naturally produces a β-lactamase.
  • β-lactamase
  • spectrum-lactamase
  • beta-lactamase

Examples

  • Bacterial resistance genes code for beta-lactamases, transferases, and other enzymes that have been customized to interfere with the drugs' actions.

    Academic text (2000)
  • Assess characteristics of extended-spectrum β-lactamase-producing Enterobacteriaceae in the current study.

    Academic text (2013)
  • And what it is, is a penicillin plus a beta lactamase inhibitor.

  • A matrix of these structures produces mucopolysaccharide and lactamase.

    Academic text (2002)
  • In 1991, Brook et al. published a study of 25 PTA specimens and reported that 13 (52%) grew beta-lactamase-producing organisms.

    Academic text (2005)
  • In view of the mixed flora that cause PTA and the increasing number of beta-lactamase-producing microorganisms, the use of antibiotics active against beta-lactamases has become more popular in clinical practice.

    Academic text (2005)
  • The bacteria that predominate in sinusitis can resist penicillin by producing beta-lactamase or by altering sites of penicillin binding.

    Academic text (2003)
  • The combination covers most respiratory pathogens, including S. pneumoniae and the beta-lactamase-producing organisms Haemophilus influenzae and Moraxella catarrhalis.

    Academic text (2006)
  • Indeed, in the United States, almost all M catarrhalis and at least 33% of H influenzae isolates produce beta-lactamase, which undermines the empiric use of drugs such as amoxicillin.

    Academic text (2003)
  • Many bacteria produce lactamase to defend themselves against antibiotics like penicillin.

Compounds

beta-lactamase
  • Specialized
7.8

A substance made by some bacteria that destroys penicillin and helps the bacteria survive antibiotics

Surface Forms

lactamase singular
lactamases plural

Morphology

lactamase = lactam (transparent) = lactam + ase

The enzyme-naming suffix '-ase' is productively added to the chemical noun 'lactam' to indicate an enzyme acting on lactams; knowing 'lactam' makes the meaning clear.

Etymology

Lactamase comes from lactam (with the root lact- meaning 'milk', seen in lactose) and the ending -ase meaning 'enzyme', like in amylase and lipase. So, lactamase is an enzyme that 'breaks down' lactam antibiotics such as penicillin, which is why it can make those drugs stop working.