hypermethylation
1
9.9
- noun
- /haɪpərˌmɛθəˈleɪʃən/
- Specialized
:
hipermetilación
- Their inactivation by promoter hypermethylation has been reported to be associated with some human cancers 5, 7, 12, 15, 24.
- promoter hypermethylation
Examples
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Like miRNAs and coding genes, T-UCR expression has been shown to be repressed by CpG island hypermethylation 85, 204.
Blog text (18) -
In a previous study, protein expression and status of promoter hypermethylation of hMLH1 and hMSH2 in 77 NSCLC tumors were studied.
Academic text (2007) -
Mechanisms involving DNA damage signaling, promoter hypermethylation of mismatch repair genes, and target drug-resistant genes after chemotherapy should also be further investigated.
Academic text (2007) -
The process of hypermethylation can lead to significant changes in gene expression.
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Scientists discovered that hypermethylation of tumor suppressor genes is linked to cancer development.
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In some cases, hypermethylation impacts DNA stability and contributes to disease progression.
Synonyms
3
7.5
A small chemical group attaches to DNA or proteins and changes gene activity
How Methylated
Surface Forms
Morphology
hypermethylation = methylation (semi-transparent) = hyper + methyl + ation
The structure is clear as hyper- plus the technical noun methylation, but the base word is specialized and not easily accessible to general learners.
Etymology
The word hypermethylation combines hyper- meaning 'too much', as in hyperactive, and methyl, which you can think of as a 'small chemical tag' that cells add to DNA. So hypermethylation means adding 'too many' methyl tags to DNA, and this extra tagging can change how genes work.