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Glite Dictionary
unmethylated

unmethylated

8.2
Not having a small chemical group called methyl attached to a molecule like DNA
  • adjective
  • /ʌnˈmɛθəˌleɪtɪd/
  • Specialized
translation icon : no metilado
  • In many cancer studies, researchers focus on unmethylated DNA to understand gene expression patterns.
  • methylated to unmethylated

Examples

  • Both methylated and unmethylated alleles were present in the liver and mammary gland tissues at the TH-INS TSS.

    Blog text (26)

  • The PKD1 locus lies in a region rich in unmethylated CpG islands (n5, n15), which suggests that it is probably rich in gene sequences.

    Academic text (1991)

  • But there are certain regions, often near promoters that are unmethylated and therefore CPGS can accumulate to higher frequencies.

  • The percentages of methylated/unmethylated (Me/un-me) CpGs represent the results from all four CpGs. # Diagram: Figure 4. The methylation status of Ltf changes during development.

    Academic text (2014)

  • Unmethylated promoters in gene sequences often indicate active transcription in various biological processes.

  • The analysis showed that the unmethylated status of certain genes was crucial for proper cellular function.

Antonyms

methylated
  • Specialized
8.2

Having a small chemical group called methyl added to it

How Methylated

methylated
  • Specialized
8.2
unmethylated
  • Specialized
8.2

Surface Forms

unmethylated positive

Morphology

unmethylated = methylated (transparent) = un + methyl + ate + ed

Formed by adding the negative prefix 'un-' to 'methylated', yielding the direct negation 'not methylated'.

Etymology

Unmethylated breaks into un- meaning 'not' and methyl meaning a small chemical 'tag' that scientists add to a molecule. So unmethylated means 'not having that methyl tag', which is why we use it for DNA or other molecules that do not have a methyl group attached.