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claudin

claudin

9.9
A protein in animal cells that helps make tight seals between cells
  • noun
  • /ˈklɔːdɪn/
  • Specialized
: claudina
  • Claudin proteins play a key role in forming tight junctions between epithelial cells in tissues.
  • immunoreactivity for claudin
  • positive for claudin
  • claudin-1 expression

Examples

  • Finally, in colorectal adenocarcinomas, claudin-1 expression can be found not only at cell-cell boundaries but also in the cytoplasm of tumor cells.

    Academic text (2007)
  • There is increasing evidence that tumor cells can show aberrant expression or abnormal cellular localization of claudin-1.

    Academic text (2007)
  • In contrast, no immunoreactivity for claudin-1 was seen in any of the other tumor types.

    Academic text (2007)
  • Our findings with regard to claudin-1 expression in meningiomas are comparable to those reported recently by Rajaram et al. 2

    Academic text (2007)
  • In total, 42 (53%) of 80 meningiomas were immunoreactive for claudin-1, whereas none of the other tumors were positive.

    Academic text (2007)
  • However, the distribution of claudin-1 in low-grade meningiomas and in other dural-based spindle cell tumors has not been elucidated fully.

    Academic text (2007)
  • The purpose of this study was to compare claudin-1 staining with other markers commonly used to differentiate meningiomas from histologic mimics.

    Academic text (2007)
  • Of the atypical meningiomas, 12 (60%) of 20 were positive for claudin-1, with 4 cases each showing 3+, 2+, and 1+ staining (8 with moderate and 4 with weak staining).

    Academic text (2007)
  • This study aimed at determining whether immunohistochemical reactivity for claudin-1 could help distinguish meningiomas from histologic mimics, compared with commonly used markers.

    Academic text (2007)
  • Of note, both the meningothelial meningioma and the atypical meningiomas that failed to stain for EMA were positive for claudin-1 (3+ and 2+, respectively).

    Academic text (2007)

Surface Forms

claudin singular
claudins plural

Morphology

claudin = close (opaque) = claud + in

Formed by a Latin-derived combining form related to 'close' plus the protein-forming suffix '-in'; the parts give a functional clue but require specialized biological/morphological knowledge.

Etymology

Claudin comes from the Latin root claud- meaning 'to close'. These proteins 'close' the gaps between cells, so the name helps you remember they make tight seals that keep tissues from leaking.