claudin
- noun
- /ˈklɔːdɪn/
- Specialized
- Claudin proteins play a key role in forming tight junctions between epithelial cells in tissues.
- immunoreactivity for claudin
- positive for claudin
- claudin-1 expression
Examples
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Finally, in colorectal adenocarcinomas, claudin-1 expression can be found not only at cell-cell boundaries but also in the cytoplasm of tumor cells.
Academic text (2007) -
There is increasing evidence that tumor cells can show aberrant expression or abnormal cellular localization of claudin-1.
Academic text (2007) -
In contrast, no immunoreactivity for claudin-1 was seen in any of the other tumor types.
Academic text (2007) -
Our findings with regard to claudin-1 expression in meningiomas are comparable to those reported recently by Rajaram et al. 2
Academic text (2007) -
In total, 42 (53%) of 80 meningiomas were immunoreactive for claudin-1, whereas none of the other tumors were positive.
Academic text (2007) -
However, the distribution of claudin-1 in low-grade meningiomas and in other dural-based spindle cell tumors has not been elucidated fully.
Academic text (2007) -
The purpose of this study was to compare claudin-1 staining with other markers commonly used to differentiate meningiomas from histologic mimics.
Academic text (2007) -
Of the atypical meningiomas, 12 (60%) of 20 were positive for claudin-1, with 4 cases each showing 3+, 2+, and 1+ staining (8 with moderate and 4 with weak staining).
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This study aimed at determining whether immunohistochemical reactivity for claudin-1 could help distinguish meningiomas from histologic mimics, compared with commonly used markers.
Academic text (2007) -
Of note, both the meningothelial meningioma and the atypical meningiomas that failed to stain for EMA were positive for claudin-1 (3+ and 2+, respectively).
Academic text (2007)
Surface Forms
Morphology
claudin = close (opaque) = claud + in
Formed by a Latin-derived combining form related to 'close' plus the protein-forming suffix '-in'; the parts give a functional clue but require specialized biological/morphological knowledge.
Etymology
Claudin comes from the Latin root claud- meaning 'to close'. These proteins 'close' the gaps between cells, so the name helps you remember they make tight seals that keep tissues from leaking.