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Glite Dictionary
autoreactive

autoreactive

1 9.9
Immune cells or antibodies that attack the body's own tissues
  • adjective
  • /ˌɔːtəˈriːæktɪv/
  • Specialized
translation icon : autoreactivo
  • However, the role of autoreactive CD4+ T cells, particularly Th1, Th17, and somewhat regulatory T cells in the pathophysiology of RA is reliable, but data in CD8+ T cells is variable.
  • autoreactive T cells

Examples

  • Tregs suppress several autoreactive responses and maintain self-tolerance in the immune system.

    Blog text (11)

  • The onset of behavioral and brain abnormalities was associated with the appearance of autoreactive antibody deposits in the brains of the sensitive mice.

    Blog text (16)

  • IL-17 also induces several chemokines responsible for the attraction of autoreactive T cells and macrophages at the site of inflammation 127.

    Blog text (17)

  • Since the main feature of several autoimmune diseases, such as rheumatoid arthritis (RA), is the inflammation and autoreactive responses, identifying the precise function of these cells in the disease course can help us design new therapeutic methods for the treatment of RA in the future.

    Blog text (11)

  • Considering the role of autoreactive T cells (particularly Th1 and Th17 cells) in the pathophysiology of RA, it might be assumed that the regulatory T cells (Tregs) will be able to control the initiation and progression of the disease.

    Blog text (11)

  • It remains to be determined if the phenotypic spectrum and fine specificity of autoreactive T-cell populations in DR4 and DR6 individuals are overlapping or entirely distinct.

    Academic text (2007)

  • All people have autoreactive immune cells that can mistakenly target their own tissues.

  • Some conditions arise when autoreactive T cells attack healthy cells in the body.

  • Research shows that autoreactive responses can lead to autoimmune diseases like lupus.

Synonyms

autoimmune
vsautoreactive
  • Specialized
32 6.0

A condition in which the body's immune system attacks its own healthy cells

focuses on immune cells or responses that directly attack that same tissue

Surface Forms

autoreactive positive

Morphology

autoreactive = reactive (semi-transparent) = auto + react + ive

The word is built transparently from 'auto' + 'reactive', but the biomedical sense 'reacting against the body's own tissues' is specialized rather than fully predictable.

Etymology

Autoreactive combines auto- 'self', as in automatic or autograph, and reactive 'showing a reaction'. So an autoreactive cell or response 'reacts' against the body's own tissues, which is why the word describes immune activity that attacks the self.