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Glite Dictionary
to upregulate

to upregulate

1 8.1
To increase the amount or activity of something inside a cell like a gene
  • verb
  • /ˌʌpˈrɛɡjʊˌleɪt/
  • Specialized
translation icon : aumentar
  • In this study, we found that shikonin upregulated the expression of -H2AX and phosphor-ATM in vitro and in vivo.
  • upregulated the expression
  • upregulate levels
  • upregulated macrophage

Maybe when you have the prism experience the the previously deemphasized synapses become upregulated without any change of axons.

Examples

  • As a result, A. baumannii substantially upregulates proteins that are associated with detoxifying reactive oxygen species.

    Academic text (2018)

  • The expression of activated caspase-3 was upregulated in septic rats.

    Academic text (2018)

  • However, its level in serum was significantly upregulated after surgery 60.

    Academic text (2017)

  • Our results showed that CD106 expression level was significantly upregulated by TNF-alpha on the third day.

    Academic text (2018)

  • In addition, it is well established that the activity of PKC is upregulated by chronic hypoxia.

    Academic text (2018)

  • In contrast, genes involved in cell division, growth, and metabolism were strongly upregulated, suggesting that bridge cells might have an increased proliferative capacity.

    Academic text (2017)

  • Furthermore, we describe how ACE activity taps into a pathway that strongly upregulates myeloid cell function.

    Academic text (2018)

  • The expression of miR-744 was markedly upregulated in pancreatic cancer and positively correlated with poor patient survival.

    Academic text (2016)

  • Overexpression of OPTN may upregulate MYOC in TM and stabilize MYOC mRNA (167).

    Academic text (2018)

  • The drug is known to upregulate the production of insulin in the pancreas.

Synonyms

to potentiate
vsto upregulate
  • Specialized
1 9.0

To make a drug or treatment work more strongly

act by increasing the amount or activity of molecules inside cells rather than boosting power

Antonyms

to downregulate
  • Specialized
1 7.6

To reduce the activity or amount of something, such as genes and proteins

How Much

to overexpress
  • Specialized
1 8.5
to upregulate
  • Specialized
1 8.1
to boost
265 2.5
to increase
∞ 1.0
to enhance
424 4.0

Surface Forms

upregulate infinitive
upregulated past
upregulated past participle
upregulating present participle
upregulates third person singular

Morphology

upregulate = regulate (transparent) = up + regulate

Meaning is directly derived from 'up' (increase) + 'regulate' (control), yielding an increase in activity or quantity.

Etymology

Upregulate combines up and regulate, where regulate comes from a root meaning 'rule' or 'measure'. So to upregulate is to 'turn up' or 'increase' the amount or activity of a gene or molecule, like turning up the volume.