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Glite Dictionary
to overexpress

to overexpress

1 8.5
Cause a gene or protein to be made in larger than normal amounts
  • verb
  • /ˌoʊvərˈɛkspres/
  • Specialized
translation icon : sobreactuar
  • Oncogenic miR-21 is highly overexpressed in several solid tumors, including glioblastoma.

Examples

  • Related to this, it would be of interest to investigate AD models which overexpress Lcn2 (besides Lcn2-deficient AD models).

    Academic text (2018)

  • Previously, we found that overexpressing Beclin 1 in a model of AD reduced disease-associated amyloid plaques.

    Academic text (2018)

  • ACE is naturally overexpressed in response to an immune challenge in the context of granulomas.

    Academic text (2018)

  • We can collect data on the how they change the molecular biology of the cell if they're overexpressed or knocked out.

  • Certain proteins are markers of cancer because they are overexpressed in the blood and other fluids of cancer patients.

    Academic text (2010)

  • Additional studies in cell lines have shown that overexpressing the C-terminal fragment sensitizes cells for apoptosis.

    Academic text (2018)

  • Degeneration of neurons overexpressing full-length APP has also been observed in vitro.

    Academic text (1992)

  • Moreover, EZH2 acts as an oncogene, as it is overexpressed in many solid cancers in both advanced and metastatic diseases.

    Academic text (2017)

  • For example, in osteosarcoma, miRs-27a and -27a* are frequently overexpressed, and the overexpression of these miRs was found to promote pulmonary metastasis formation in vivo.

    Academic text (2016)

  • In his experiments, the scientist aimed to overexpress the specific gene to study its effects on cell growth.

Synonyms

to overproduce for
vsto overexpress
6.7

To make more goods than are needed for an event or sale

refers specifically to causing a biological molecule to be made in larger amounts in labs

How Expressed

to overexpress
  • Specialized
1 8.5
to express
  • Specialized
24 8.4

Surface Forms

overexpress infinitive
overexpressed past
overexpressed past participle
overexpressing present participle
overexpresses third person singular

Morphology

overexpress = express (semi-transparent) = over + express

The prefix 'over' combined with 'express' yields 'express excessively', but the specific biological usage (produce more of a gene or protein) is technical and may be unfamiliar to general learners.

Etymology

Overexpress comes from the parts over- meaning 'too much' and express meaning 'to show' or 'to make'. Think of express like when you 'express' a feeling, so to overexpress a gene or protein is to make it 'show' itself 'too much', in other words to be made in too large an amount.