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translocation

translocation

1 9.5
Exchange of parts between two different chromosomes that can cause genetic disease
  • noun
  • /ˌtrænzloʊˈkeɪʃən/
  • Specialized
: translocación genética
  • Their telomeres became shorter than normal, their chromosomes broke, and some nonhomologous chromosomes fused to form translocations.
  • result of translocation

Examples

  • The odd part about miscarrying for me was that my mom had only me, then developed genetic translocation, a chromosomal disorder where a woman can conceive a baby but cannot carry it to term.

    Blog text (29)
  • Here a translocation has taken place so that the structure of the chromosome is abnormal.

  • The 1990s witnessed an explosion of new knowledge about the genetics of cell-to-cell signaling and coordinated gene translocation for defense and virulence factors.

    Academic text (2003)
  • In the evolutionary context, Haldane deals for the first time with inversions and translocations, polyploidy, and hybridization.

    Academic text (1992)
  • Pediatric soft tissue sarcomas are rare tumors of childhood, frequently characterized by specific chromosome translocations.

    Blog text (9)
  • Because typical translocation could not be found in the FISH study, it was believed this may reflect a subgroup of peripheral PNETs (pPNETs), which lack this genetic change.

    Academic text (2015)
  • The alveolar type has consistently been marked by a translocation of chromosomes (2; 13) (q35q14); in the embryonal type, the maternal allele is lost.

    Academic text (2005)
  • Researchers discovered that the translocation of genetic material between chromosomes can lead to certain cancers.

  • The study of translocation in chromosomes helped scientists understand various genetic disorders.

  • A certain translocation was identified in the patient's genome, which contributed to their unusual symptoms.

Surface Forms

translocation singular

Morphology

translocation = translocate (semi-transparent) = trans + locate + ion

Formally 'trans-' + 'locate' + '-ion' (movement across places), but the genetic sense is a technical extension referring to exchange or relocation of chromosome parts, which is less immediately obvious to an average learner.

Etymology

Translocation comes from the parts trans- ('across') and locate ('place'). In genetics it means when parts of a chromosome have been moved 'across' to a new place, so imagining pieces being moved from one place to another on the chromosomes makes the meaning clear.