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refractory

refractory

1 8.9
Not responding to medical treatment for a disease
  • adjective
  • /rɪˈfræk.tər.i/
  • Specialized
translation icon : refractario al tratamiento
  • Each of these has three subcategories: untreated, previously treated, and refractory to treatment.
  • refractory to treatment
  • refractory disease
  • refractory symptoms

So your ovaries now have no eggs or so few eggs that they are refractory to the brain sending out FSH.

Examples

  • The commonest clinical finding in these patients is refractory ascites.

    Academic text (2003)
  • Patients with multifocal metastatic bone disease that is refractory to routine treatments may benefit.

    Academic text (2007)
  • A subsequent course of antibiotic therapy was initiated, but the symptoms were refractory to treatment.

    Academic text (2005)
  • Traditionally, the management of refractory epistaxis has followed a sequential pattern.

    Academic text (2005)
  • Surgery is reserved for refractory disease in patients with symptomatic blockage.

    Academic text (2008)
  • For spasticity that impairs functioning and is refractory to conservative management, medications may be indicated.

    Academic text (2004)
  • Narcotic analgesics (category C) should be reserved for those patients whose pain is refractory to more conservative approaches.

    Academic text (2003)
  • Septic shock is defined as hypotension <90 mmHg or >40 mmHg from baseline that is refractory to fluid resuscitation.

    Academic text (2005)
  • Renovascular disease is an important and often unrecognized contributor to renal insufficiency, refractory hypertension, and overall cardiovascular mortality.

    Academic text (2007)
  • The patient's condition was refractory to standard treatments, causing concern among the doctors.

Synonyms

stubborn
vsrefractory
16 3.3

Hard to remove or cure even after trying

focuses on resistance to efforts broadly rather than only medical cases
nonresponsive
vsrefractory
  • Specialized
6.0

Not improving after treatment or medicine

is a stronger sense of persistent resistance to medical intervention

Antonyms

61 4.0

React quickly and helpfully to people and things

treatable
  • Specialized
31 3.5

A condition a doctor or medicine can cure

Compounds

refractory anemia
  • Specialized
8.9

A condition with low red blood cells that does not get better with usual treatments and needs blood transfusions

refractory period
  • Specialized
8.7

A short time after a nerve or muscle sends a signal when it cannot respond to another one

refractory pot
  • Specialized
9.9

A small heatproof bowl made of bone ash to separate metals like gold or silver during testing

refractory-lined
  • Specialized
9.9

With an inner layer of heatproof material that protects against very high heat

How Treatable

curable
14 4.1
treatable
  • Specialized
31 3.5
refractory
  • Specialized
1 8.9
untreatable
  • Specialized
5 6.5

Surface Forms

refractory positive

Morphology

refractory = refract + ory

The adjective reflects an older Latin formation rather than a clear modern prefix+root+suffix analysis, so learners cannot reliably derive 'resistant to treatment' from the visible parts.

Etymology

Refractory originally meant 'stubborn' or 'hard to change' from Latin roots like frangere ('to break'), which led to the idea of resistance. So a refractory disease is one that 'resists' medical treatment and does not get better easily.