quinolone
1
9.8
- noun
- /ˈkwɪnəˌloʊn/
- Specialized
- What is the possibility that quinolones select for resistant strains in the mastoid cavity, middle ear cleft, and eustachian tube?
Examples
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Quinolones are synthetic derivatives of nalidixic acid, which was discovered during the purification of the antimalaria agent chloroquine.
Academic text (2005) -
We are also studying resistance patterns in the post-quinolone era.
Academic text (2002) -
The quinolones are very stable; in fact, some are almost nondegradable.
Academic text (2005) -
The pharmacokinetic properties of the quinolones include good penetration
Academic text (2005) -
The control of granulation tissue requires the administration of an appropriate anti-infective, either a quinolone or an aminoglycoside.
Academic text (2002) -
This is because the definition of "quinolone resistance" is based on systemic rather than topical breakpoints.
Academic text (2005) -
Dr. Rutka: Systemic quinolones are associated with some significant adverse effects and drug interactions.
Academic text (2005) -
Prof. Ovesen: Can the quinolones affect the susceptibility patterns of colonizing bacteria?
Academic text (2005) -
However, Barlow et al., in their study of the quinolone derivative ofloxacin, found that its effect on the middle ear mucosa and the tympanic membrane was no different from that of 0.9% isotonic sodium chloride solution.
Academic text (1998) -
Quinolones are commonly used in research as a chemical scaffold for developing new antibiotics.
Surface Forms
Morphology
quinolone = quinoline (transparent) = quinoline + one
Formed by adding the chemical suffix '-one' to 'quinoline', indicating a ketone derivative; the construction directly names the chemical structure.
Etymology
The word quinolone comes from the chemical name quinoline plus the ending -one, which in chemistry marks a 'ketone', a simple oxygen-containing group. So a quinolone is a quinoline that has that ketone part, and the name points to this specific chemical structure.