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Glite Dictionary
phosphorylation

phosphorylation

3 6.8
Adding a small chemical called phosphate to a molecule in cells to change its activity or store energy
  • noun
  • /fɑːsˌfɔːrɪˈleɪʃən/
  • Specialized
translation icon : fosforilación
  • The phosphorylation of glucose plays a critical role in cellular metabolism.
  • oxidative phosphorylation
  • phosphorylation of proteins
  • activation by phosphorylation

Examples

  • MYPT-1 acts as the principal downstream effector protein of ROCK, whose phosphorylation level may indirectly reflect the activity of ROCK (20).

    Academic text (2018)

  • Brief alcohol exposure increases phosphorylation of heat shock protein 90 (HSP90) in isolated demembranated bovine tracheal cilia.

    Academic text (2016)

  • And so this work includes the phosphorylation of ATP.

  • Attempts to block the aberrant phosphorylation of tau protein could have therapeutic potential.

    Academic text (1992)

  • However, the exact biochemical link between increased cellular ACE activity and increased phosphorylation of p47-PHOX is still under active investigation.

    Academic text (2018)

  • Thus, phosphorylation of ATM is an indirect indicator reflecting DNA DSBs.

    Academic text (2016)

  • These lab results confirm what I've been preaching for years, that phosphorylation is key to enzyme absorption.

    Extraordinary Measures (2010)

  • Proteins associated with oxidative phosphorylation and mitochondria were significantly overrepresented within the list of differentially expressed proteins.

    Academic text (2010)

  • High Pim-1 expression and p21 phosphorylation are associated with poor prognosis in various cancers 29, 73, 76.

    Academic text (2017)

  • The anti-Raf-1 affibody was found to reduce phosphorylation of Erk1/2 (downstream of the Ras/Raf pathway) in EGF-stimulated HEK293T cells.

    Academic text (2017)

Compounds

oxidative phosphorylation
  • Specialized
8.1

A process in mitochondria that makes ATP using oxygen and food

Surface Forms

phosphorylation singular
phosphorylations plural

Morphology

phosphorylation = phosphorylate (semi-transparent) = phosphoryl + ate + ion

A straightforward nominalization formed by adding the productive suffix '-ion' to the verb 'phosphorylate', yielding the process noun.

Etymology

Phosphorylation comes from phospho-, an old root meaning 'light', seen in phosphorus, and from phosphate, the chemical 'phosphate' that cells add. So, phosphorylation means adding a phosphate to a molecule, which often gives energy or changes how that molecule works.