phase I clinical trial
1
4.3
- noun
- /feɪz aɪ ˈklɪnɪkəl traɪəl/
- Specialized
:
ensayo clínico de fase I
- The primary objective of this phase I clinical trial is to establish a dosage that is safe.
Examples
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Many drugs that do well in early lab tests or phase I clinical trials may not do so well in later trials.
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Even though Phase I clinical trials are not indication-specific and therefore have already been carried out, this is not the case for Phase II and III trials that relate to specific indications.
Academic text (2016) -
These findings are in accordance with several phase I clinical trials that used tumor-derived exosomes or exosome-pulsed DCs as cancer vaccines.
Academic text (2017) -
Researchers in France are taking advantage of the progress in genetic and molecular profiling to analyze the makeup of individual cancer patients' tumors and, using this information, assign them to particular treatments and phase I clinical trials—an approach that could become part of everyday clinical practice.
Blog text (14) -
Delta-tocotrienol is now in phase I clinical trials at the Moffitt Cancer Center in Florida for the treatment of pancreatic cancer.
Synonyms
67
3.9
A controlled test with people to see if a new medicine is safe and works
3
3.7
A carefully controlled study giving a new medicine or device to people to see if it is safe and works
2
4.3
The first stage of a medical test with a few people to check safety and the right drug amount
How Advanced
- Specialized
- Specialized
1
5.0
- Specialized
- Specialized
1
4.3
- Specialized
Surface Forms
Morphology
The phrase is directly compositional: 'phase' = stage, 'I' = one/first (Roman numeral), 'clinical' = medical/patient-related, and 'trial' = testing, so together they straightforwardly denote the first stage of medical testing. Although the topic is technical, the meaning follows standard naming/numbering conventions (Phase I), making it predictable to learners who know the constituent words.
Etymology
Phase I clinical trial comes from thinking of drug testing as a series of steps: the word phase means a first step and a trial is a test. So a phase I clinical trial is the first small test of a new treatment to check 'safety' and the right 'dose' in a 'small group'.