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Glite Dictionary
oncogenesis

oncogenesis

9.3
A process in which normal cells change into cancer cells
  • noun
  • /ˌɑnkoʊˈdʒɛnɪsɪs/
  • Specialized
translation icon : oncogénesis
  • The bcl-2 protein is a proto-oncogene that promotes oncogenesis by blocking programmed cell death (apoptosis).

Examples

  • Exosomes may also play a role in the activity of p53, the gatekeeper of the genome, by disrupting tumor suppression functions, a fundamental mechanism of oncogenesis.

    Academic text (2017)

  • This really changes our view of the role of viruses in oncogenesis and it changes it in a quite a fundamental way.

  • Epidemiological studies have established the link between HBV infection and HCC, yet the mechanism of oncogenesis has not been elucidated.

    Academic text (1994)

  • The bcl-2 protein is a proto-oncogene that promotes oncogenesis by blocking programmed cell death (apoptosis).

    Academic text (2008)

  • Evidence is accumulating that herpes simplex virus (HSV) infection is implicated in oncogenesis.

    Academic text (2006)

  • Research has shown that mutations in certain genes can initiate oncogenesis, ultimately leading to the formation of tumors.

  • Understanding the mechanisms of oncogenesis can help scientists develop targeted therapies for various types of cancer.

Synonyms

neoplasia
vsoncogenesis
  • Specialized
1 9.4

Abnormal, uncontrolled cell growth that forms a lump or tumor

refers specifically to malignant cell transformation rather than general uncontrolled growth
carcinogenesis
vsoncogenesis
  • Specialized
1 7.5

The process by which normal cells change into cancer cells

is the preferred scientific term for this cell transformation process
tumorigenesis
vsoncogenesis
  • Specialized
1 8.2

Cells grow in an abnormal way and form a lump in the body

focuses instead on individual cells becoming cancerous rather than tumor formation
cancerization
vsoncogenesis
  • Specialized
9.9

Normal tissue changes into cancer cells

emphasizes cell-level transformation rather than tissue-level change

How Advanced

metastasis
  • Specialized
4 7.8
invasion
  • Specialized
25 5.7
progression
62 3.8
oncogenesis
  • Specialized
9.3
initiation
15 4.7

Surface Forms

oncogenesis singular
oncogeneses plural

Morphology

oncogenesis = genesis (opaque) = onco + genesis

The term 'oncogenesis' is specialized and not easily deduced from its parts without specific medical knowledge.

Etymology

Oncogenesis comes from Greek parts onco- meaning 'tumor' and -genesis meaning 'origin' or 'creation'. Think of -genesis like the words generate and genetic, which are about 'making', so oncogenesis is the 'making of a tumor' — the process that turns normal cells into cancer cells.