nonsynonymous
- adjective
- /ˌnɒnˈsɪnəˌməs/
- Specialized
:
no sinónimo
- In this region, we identified one nonsynonymous and three synonymous changes.
- nonsynonymous single-nucleotide
- nonsynonymous substitution
Examples
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After sequencing, they discovered a nonsynonymous point mutation in the spoT gene.
Blog text (26) -
One nonsynonymous single-nucleotide variant (variant position G19042U, amino acid substitution S6348I) was detected in the polyprotein coding sequences.
Academic text (2015) -
We identified 106 nonsynonymous single-nucleotide variations (SNVs) and 7 small insertions or deletions (INDELs) in the 52 patients.
Academic text (2018) -
By using a sequence-based approach, Diavatopoulos et al. analyzed 7 B. holmesii isolates and observed only 1 nonsynonymous polymorphism among 3,666 bases (16).
Academic text (2012) -
Of note, 7 single-nucleotide variants are located in the aforementioned variable region in the S protein coding sequences, 5 of which are nonsynonymous (Table), thereby confirming the high variability in the N-terminal part of the S protein.
Academic text (2015) -
Huang et al. (2014) identified variants in the set of 200 DGRP fly strains that potentially generate a damaged protein, and found that such variants are typically less frequent than other sites (e.g., nonsynonymous variants).
Academic text (2017) -
We also determined whether differentially expressed genes in each treatment group contained polymorphisms, including nonsynonymous single nucleotide polymorphisms (SNP), codon deletion, frameshift, etc.
Academic text (2016) -
The researchers discovered a nonsynonymous mutation in the protein sequence, which affected its function.
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A nonsynonymous change at the third codon significantly altered the structure of the resulting protein.
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They noted that the nonsynonymous variation resulted in an amino acid change that could impact disease susceptibility.
Synonyms
Describing a change in DNA that makes one amino acid in a protein different
How Synonymous
46
4.9
- Specialized
Surface Forms
Morphology
nonsynonymous = synonymous (semi-transparent) = non + synonym + ous
Formally non- + synonymous is clear, but in genetics 'synonymous' has a specialized technical sense referring to codons that do not change the amino acid, so general learners may not infer the genetic meaning.
Etymology
Nonsynonymous is made from non- ('not') and synonym ('same meaning'), so it literally means 'not the same'. In genetics, a nonsynonymous change makes a different protein from the gene, which is why the word reminds you the result is not the same.