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Glite Dictionary
🧬 Amino acid change 🧬 Mutation in gene
missense

missense

9.7
Describing a change in DNA that makes one amino acid in a protein different
  • adjective
  • /ˈmɪsˌsɛns/
  • Specialized
translation icon : cambio de sentido
  • The study focused on how missense mutations can alter the function of crucial proteins in the body.
  • missense mutation

Examples

  • Patients carrying the missense mutation had similar presentations, except for DSD0011.

    Academic text (2018)

  • They also found that the missense and mismatched control ODNs had only slight effects.

    Academic text (2017)

  • More recently, a missense mutation (L148M) in PNPLA3 was associated with an increased risk of developing NAFLD.

    Blog text (27)

  • Missense mutations of p53 are associated with prolonged protein half-life, which enables the immunohistochemical detection of p53 mutations.

    Academic text (1995)

  • A missense mutation in the gene led to a significant change in the protein structure.

  • Researchers discovered that the missense variant significantly affected the patient's response to treatment.

Synonyms

nonsynonymous
vsmissense
  • Specialized
9.3

A genetic change that alters the amino acids in a protein

is a specific type meaning one amino acid is replaced by another

Surface Forms

missense positive

Morphology

missense = sense (opaque) = mis + sense

The prefix 'mis-' typically implies incorrectness, but the specific genetic context of 'missense' is not directly derivable from 'sense'.

Etymology

Missense comes from the parts mis- ('wrong'), the same mis- in mistake, and sense ('meaning'). So a missense change gives the DNA a 'wrong meaning' and makes a different amino acid appear in a protein.