letrozole
1
8.1
- noun
- /ˈlɛtrəzoʊl/
- Specialized
:
letrozol
- Data from the MA-17 trial indicate no overall adverse effect of letrozole on quality of life, but small, though significant, worse outcomes in body pain and vasomotor symptoms 54.
- letrozole, an aromatase inhibitor
- an aromatase inhibitor
- patients taking letrozole
Question about the letrozole prevent estrogen production.
- Question about the letrozole prevent estrogen production.
Examples
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In the MA-17 trial at 2.4 years, rates of osteoporosis (of any grade) were 5.8% with letrozole and 4.5% with placebo (P = 0.07).
Blog text (13) -
Similarly, in the BIG 1-98 trial, letrozole was associated with fewer thromboembolic events compared with tamoxifen (1.5% versus 3.5%, P < 0.001).
Blog text (13) -
The use of letrozole, an aromatase inhibitor, has been investigated.
Academic text (2018) -
In the extended adjuvant setting, letrozole was not associated with more cardiovascular events than placebo at a median follow-up of 2.4 years.
Blog text (13) -
At present, it is not clear whether the early concerns with cardiac morbidity in the BIG 1-98 trial are specific to letrozole or are a class effect of AIs.
Blog text (13) -
Also, OS has been shown to improve in node-positive patients treated with letrozole in the extended adjuvant trial after 5 years of tamoxifen versus placebo.
Blog text (13) -
The results published in 2005 in favor of letrozole led to the unblinding of the tamoxifen-alone arm, and 25.2% of the patients selectively switched to letrozole for a median duration of 18 months.
Blog text (13) -
The effect of 'delayed' extended adjuvant therapy with letrozole has been evaluated in those women who, after unblinding of the trial, opted for an unplanned switch from placebo to letrozole.
Blog text (13) -
More recent analysis of the MA-17 trial now indicates a survival benefit for extended adjuvant therapy with letrozole in lymph node-positive patients (HR 0.61, P = 0.04).
Blog text (13) -
The medication letrozole is often prescribed to postmenopausal women to lower estrogen levels and treat breast cancer.
Synonyms
23
6.3
A drug that blocks the hormone estrogen to treat and prevent breast cancer
A medicine used to treat some types of cancer like breast, lung, or prostate
Surface Forms
Etymology
The word letrozole ends with the familiar drug ending -zole, which often marks medicines that 'block' a chemical step in the body. That's why letrozole lowers the hormone 'estrogen' and is used to treat some breast cancers in women after menopause.