knockout
4
7.5
- noun
- /ˈnɑːkˌaʊt/
- Specialized
:
mutante nulo
- When receptor deficiency was produced in mice by genetic knockout, an anxiety-like phenotype was observed (Toth, 2003).
- knockout mice
- gene knockout
- knockout mutants
Examples
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However, all homozygous knockout mutants died within a few days.
Academic text (2009) -
Yeah, what you mentioned this growth hormone knockout mice that are known to live longer.
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As the researchers had expected, the knockout mice did not fare well.
Academic text (1998) -
You can make a knockout mouse where the Preston is knocked out.
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To our great surprise, though, when the spores developed, the knockout was underrepresented compared to the wild type.
Academic text (2007) -
One investigation removed telomerase in knockout mice and observed the onset of senescence.
Academic text (1998) -
Sure enough, when we mixed the knockout with wild-type cells, the knockout was overrepresented among the spore-forming cells at the slug stage.
Academic text (2007) -
In addition, the miR-126 knockout significantly augmented susceptibility of leukemic cells to standard chemotherapy.
Academic text (2016) -
The het x het crosses resulted in offspring, which included knockout mice that were viable and fertile without noticeable differences compared to wild-type mice.
Academic text (2017) -
The scientists used knockout mice to learn more about the function of a specific gene.
Compounds
How Reduced
- Specialized
4
7.5
- Specialized
1
9.3
Surface Forms
Morphology
Etymology
Knockout in genetics borrows the image of knock + out: scientists 'knock out' a gene to make it 'stop working', so a 'knockout' animal or cell has that gene switched off.