downregulation
1
7.7
- noun
- /ˌdaʊnˌrɛɡjʊˈleɪʃən/
- Specialized
:
downregulación
- Moreover, O-glycosylation inhibitors showed induction of apoptosis and downregulation of proliferation in colorectal cancer cells 126.
Examples
-
Reduced disease development was associated with downregulation of ex vivo IL-17 and IL-6 synthesis.
Blog text (17) -
Most of these (e.g., genetic variation, downregulation of MHC, antibody-viral complexes) are independent of IFN activity. IFNs do contribute modestly to viral resistance.
Academic text (2007) -
Based on our findings thus far, we hypothesized that this effect may be associated with the downregulation of osteocalcin.
Blog text (6) -
More importantly, a correlation was established between altered membrane repolarization observed in the QT interval and the downregulation of Ito.
Academic text (2016) -
There is also evidence showing the anti-myeloma activity of triptolide through downregulation of both histone H3K9 and H3K27 methylation.
Academic text (2017) -
In vitro, miR-155 prevents T cell secretion of IL-4 through downregulation of MAF 85,86.
Academic text (2016) -
Our analysis revealed a downregulation in genes essential to the repair program in bSCs, such as genes involved in inflammation, immune signaling, and ECM production, and a decrease in transcriptional activity.
Academic text (2017) -
The downregulation of 3Gn-T6 and C3GnT was shown to suppress metastasis in colon carcinoma, suggesting that core structures may play a key role in cancer progression.
Academic text (2016) -
When taken up by dendritic cells, MUC2-coated antigens induce specific downregulation of inflammatory signals while leaving the production of regulatory cytokines unchanged (Figure 1) 70.
Academic text (2016) -
The researchers discovered that downregulation of specific receptors can enhance the effectiveness of certain cancer treatments.
Synonyms
6
7.5
An action that reduces the activity of a nerve or body part
1
9.3
A lab method that lowers a gene's activity to show what the gene does
Antonyms
How Reduced
Surface Forms
Morphology
downregulation = downregulate (transparent) = down + regulate + ion
The noun is formed by adding a standard nominalizing suffix to the verb 'downregulate' (down- + regulate), so the reduction meaning is directly derived.
Etymology
Downregulation starts with down ('lower') and has the part regulate ('control' or 'rule'), like the familiar word regular. So in biology it means lowering the number or activity of cells, receptors, or molecules to reduce a response.