cyclosporine
1
5.5
- noun
- /ˌsaɪkləˈspɔːriːn/
- Specialized
:
ciclosporina
- Islet cell damage associated with tacrolimus and cyclosporine: morphological features in pancreas allograft biopsies and clinical correlation.
- cyclosporine therapy
- patients on cyclosporine
- the cyclosporine drug
Examples
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The incidence of rhabdomyolysis increases dramatically when statins are co-administered with drugs that inhibit their hepatic transformation, such as cyclosporine or azoles.
Academic text (2007) -
In summary, our data indicate that TGF-1 and PDGF could be the principal mediators of progressive renal allograft dysfunction that might be induced by cyclosporine A.
Academic text (2007) -
In 1983, the introduction of the immunosuppressant drug cyclosporine greatly reduced the rejection rates of transplanted organs.
Academic text (1998) -
Two patients received regimens of cyclosporine and prednisolone or mycophenolate mofetil and prednisolone.
Academic text (2012) -
He also had end-stage renal disease secondary to cyclosporine toxicity and required hemodialysis.
Academic text (2001) -
All three recipients received basiliximab induction and triple maintenance immunosuppressive therapy with prednisone, mycophenolate mofetil, and cyclosporine A.
Academic text (2012) -
In experimental models, cyclosporine A (CsA) administration produced a similar histological appearance to those found in transplant recipients with chronic allograft nephropathy that was associated with increased TGF-1 expression.
Academic text (2007) -
Conclusion: Our data confirm the crucial contribution of the profibrotic cytokines TGF-1 and PDGF in the development of chronic graft dysfunction that could be further augmented by cyclosporine A therapy.
Academic text (2007) -
Cyclosporine is often prescribed to patients to help prevent organ rejection after surgery.
-
After the kidney transplant, the doctor advised the patient to take cyclosporine to suppress the immune response.
Synonyms
1
6.1
A drug that weakens the body's immune system to stop it rejecting a new organ
1
3.9
A drug that makes the body's immune system weaker to prevent organ rejection or treat autoimmune disease
1
9.8
A drug that lowers the body's immune response to prevent organ rejection and treat autoimmune disease
A drug that lowers the body's natural defence to prevent organ rejection
A drug that lowers the body's natural defense to stop organ rejection or treat diseases where the body attacks itself
Drug that makes the body's immune system weaker
A medicine that weakens the immune system to treat diseases where the body attacks itself and to prevent transplant rejection
Surface Forms
Morphology
cyclosporine = cyclosporin (opaque) = cyclo + sporin + ine
The parts are technical chemical combining forms ('cyclo-' and 'sporin') and a chemical suffix '-ine' that are not productive English morphemes for average learners, so the meaning cannot be derived from the components.
Etymology
The word cyclosporine comes from parts meaning cyclo- 'circle' and spore 'spore', because the medicine was first found in a spore-making fungus and its active part is ring-shaped. So the name points to a fungal, ring-shaped drug that lowers the immune response to help prevent organ rejection after a transplant.