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Glite Dictionary
🧬 Opposite DNA strand 🧬 Gene-blocking molecule
antisense

antisense

1 9.9
A short DNA or RNA molecule that attaches to messenger RNA to stop it from making a protein
  • noun
  • /ˈæntiˌsɛns/
  • Specialized
: antisentido
  • Results show an overlap of nucleotides at adenine 643, or homologous thymidine, when analyzed in both the sense and antisense orientations.
  • antisense oligonucleotides

Examples

  • Antisense drugs, gene therapy, microsurgical applications.

    Exam (2009)

  • Single-stranded DNA or RNA molecules with sequences complementary to the mRNA of the target gene (referred to as antisense molecules) can be synthesized in vitro.

    Academic text (1992)

  • So I want your comments on antisense technologies, whether we could use it in a timely fashion and great.

  • That is why in 2006 the Nobel Prize in Medicine went to the inventors of a technology called antisense, or more specifically, RNA interference.

    Blog text (4)

  • HOTAIR - HOX antisense intergenic RNA

    Blog text (18)

  • Also, Oct4 has been reported to be controlled by pseudogene-expressed antisense RNAs (asRNAs) (summarized in Ref. 67).

    Academic text (2016)

  • Antisense oligonucleotides (ASO) that mimic naturally occurring RNA/DNA are highly unstable and are very rapidly degraded by nucleases.

    Academic text (2016)

  • Scientists developed an antisense molecule to inhibit the production of the disease-causing protein.

  • The researchers used antisense RNA to block the expression of the target gene effectively.

  • To study gene regulation, they designed an antisense strand that pairs with the messenger RNA.

Surface Forms

antisense singular
antisenses plural

Morphology

antisense = antisense (semi-transparent) = anti + sense

This noun is a nominalized use of the adjective antisense, so the form is unchanged but the part of speech shifts.

Etymology

Antisense comes from the parts anti- 'against' and sense 'the coding message'. As a noun, an antisense is a piece of DNA or RNA that is the opposite of the message strand, so it can stick to that strand and stop or change the genetic message.