Cox-2 inhibitor
1
4.7
- noun
- /kɒks tuː ɪˈhɪbɪtə/
- Specialized
:
inhibidor de Cox-2
- Doctors often prescribe COX-2 inhibitors to patients suffering from arthritis to help reduce pain and inflammation.
- Cox-2 inhibitor drug
- selective Cox-2 inhibitors
- new Cox-2 inhibitors
Examples
-
The selective COX-2 inhibitor group of nonsteroidal anti-inflammatory drugs (NSAIDs) was introduced in the late 1990s.
Academic text (2011) -
These new drugs are called COX-2 inhibitors because of their ability to bypass the COX-1 prostaglandins that protect the stomach and are designed to act directly on the COX-2 prostaglandins, which are the cause of the inflammation.
Academic text (2002) -
The underlying scientific goal was to find a COX-2 inhibitor without COX-1 inhibition.
Blog text (11) -
The two FDA-approved COX-2 inhibitors on the market today are celecoxib and rofecoxib.
Academic text (2002) -
COX-2 inhibitors block the synthesis of prostaglandins in the body, like PGE2 and PGD2.
Blog text (11) -
I believe a similar cycle has kept the FDA from acting to ban the use of COX-2 inhibitors to treat chronic pain and inflammation in autoimmunity.
Blog text (11) -
While the cardiovascular deaths that resulted from the Vioxx fraud were certainly bad, they pale in comparison to the ongoing damage caused to autoimmune patients by the entire class of COX-2 inhibitors still on the market.
Blog text (11) -
Many people rely on COX-2 inhibitors for relief from chronic pain without the side effects associated with traditional painkillers.
-
Recent studies indicate that COX-2 inhibitors can be effective in managing symptoms of inflammatory bowel disease.
Synonyms
4
3.5
A medicine that lowers pain, fever, and swelling without using steroids
3
3.4
Medicine that reduces swelling and pain
1
3.5
A medicine that reduces swelling and pain in the body
How Selective
- Specialized
1
4.7
- Specialized
4
3.5
Surface Forms
Morphology
The term is compositionally transparent: COX-2 (an enzyme that produces inflammatory prostaglandins) combined with inhibitor (a substance that inhibits) straightforwardly yields 'a substance that inhibits COX-2', so a learner who knows both constituents can infer it reduces inflammation/pain. Although the item is technical, the noun–noun compound logic is regular and cross-linguistically obvious, making the meaning predictable from the parts.
Etymology
Cox-2 inhibitor comes from its job in the body: it blocks a specific enzyme called COX-2 while leaving a similar enzyme, COX-1, alone. Think of it as stopping only the worker that makes pain and swelling while leaving the helper for the stomach, so the name means 'a drug that blocks COX-2 to reduce pain and inflammation'.