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Cox-2

Cox-2

1 5.7
A protein in the body that helps make chemicals causing swelling, pain, and fever
  • noun
  • /kɒks tuː/
  • Specialized
translation icon : Cox-2
  • Our functional study revealed that COX-2 plays an important role in arsenic-induced angiogenesis, which can be impaired by miR-199a overexpression.
  • COX-2 expression
  • COX-2 promoter
  • induced COX-2

Examples

  • In addition, miR-199a-3p has also been reported to target COX-2 in human chondrocytes (Akhtar and Haqqi 2012).

    Academic text (2014)
  • In this study, we observed that both HIF-1 and COX-2 expression levels were dramatically up-regulated in AsT cells.

    Academic text (2014)
  • We speculate whether there is an interaction between HIF-1 and COX-2 in this context.

    Academic text (2014)
  • The two FDA-approved COX-2 inhibitors on the market today are celecoxib and rofecoxib.

    Academic text (2002)
  • We observed a dramatic decrease in angiogenic potential in COX-2 knockdown cells (Figure 5B).

    Academic text (2014)
  • The COX-2 expression was almost undetectable in parental BEAS-2B cells, but it was pronouncedly expressed after chronic arsenic exposure.

    Academic text (2014)
  • Here, we provide a link in which repression of miR-199a by arsenic-induced ROS activates HIF-1 and COX-2 expression.

    Academic text (2014)
  • As shown in Figure 4D, antibody against HIF-1 was able to pull down the COX-2 promoter, suggesting the association between HIF-1 and the COX-2 gene.

    Academic text (2014)
  • We validated the binding sites by constructing COX-2 promoter luciferase reporters with wild-type or mutant HRE.

    Academic text (2014)
  • The researcher focused on the role of COX-2 in inflammation and pain management during the study.

Synonyms

cyclooxygenase-2
vsCox-2
  • Specialized
7.9

A body protein that helps make chemicals that cause pain, swelling, and fever

is the shorter, abbreviated form of the same enzyme name

Surface Forms

Cox-2 singular

Etymology

Cox-2 is short for cyclooxygenase-2, which breaks into cyclo- ('ring'), oxygen ('oxygen'), and -ase ('enzyme ending'). That name shows it is an enzyme that uses oxygen to change ring-shaped chemicals into substances that cause inflammation, pain, and fever, so blocking Cox-2 can reduce those symptoms.