Cox-2
- noun
- /kɒks tuː/
- Specialized
- Our functional study revealed that COX-2 plays an important role in arsenic-induced angiogenesis, which can be impaired by miR-199a overexpression.
- COX-2 expression
- COX-2 promoter
- induced COX-2
Examples
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In addition, miR-199a-3p has also been reported to target COX-2 in human chondrocytes (Akhtar and Haqqi 2012).
Academic text (2014) -
In this study, we observed that both HIF-1 and COX-2 expression levels were dramatically up-regulated in AsT cells.
Academic text (2014) -
We speculate whether there is an interaction between HIF-1 and COX-2 in this context.
Academic text (2014) -
The two FDA-approved COX-2 inhibitors on the market today are celecoxib and rofecoxib.
Academic text (2002) -
We observed a dramatic decrease in angiogenic potential in COX-2 knockdown cells (Figure 5B).
Academic text (2014) -
The COX-2 expression was almost undetectable in parental BEAS-2B cells, but it was pronouncedly expressed after chronic arsenic exposure.
Academic text (2014) -
Here, we provide a link in which repression of miR-199a by arsenic-induced ROS activates HIF-1 and COX-2 expression.
Academic text (2014) -
As shown in Figure 4D, antibody against HIF-1 was able to pull down the COX-2 promoter, suggesting the association between HIF-1 and the COX-2 gene.
Academic text (2014) -
We validated the binding sites by constructing COX-2 promoter luciferase reporters with wild-type or mutant HRE.
Academic text (2014) -
The researcher focused on the role of COX-2 in inflammation and pain management during the study.
Synonyms
A body protein that helps make chemicals that cause pain, swelling, and fever
Surface Forms
Etymology
Cox-2 is short for cyclooxygenase-2, which breaks into cyclo- ('ring'), oxygen ('oxygen'), and -ase ('enzyme ending'). That name shows it is an enzyme that uses oxygen to change ring-shaped chemicals into substances that cause inflammation, pain, and fever, so blocking Cox-2 can reduce those symptoms.