succinate
1
7.2
- noun
- /ˈsʌkɪneɪt/
- Specialized
- In the citric acid cycle, the enzyme succinate dehydrogenase converts succinate to fumarate.
- succinate as substrate
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Watch on YouTubeI've heard that shiver causes the release of succinate, which then activates the brown fat.
- I've heard that shiver causes the release of succinate, which then activates the brown fat.
- The science eventually shifted over to succinate as the main factor in cold induced thermogenesis through this brown fat pathway.
Examples
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The emergency medicine is methylprednisolone sodium succinate (Solu-Medrol)—this is used to treat asthma and is very effective at improving outcomes.
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Methylprednisolone sodium succinate is injectable for asthma, but this is not the drug involved.
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All right, now we get to the succinate step and we said, well, it was here.
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The other way is we can convert fumarate, sorry, succinate to fumarate.
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The science eventually shifted over to succinate as the main factor in cold induced thermogenesis through this brown fat pathway.
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I've heard that shiver causes the release of succinate, which then activates the brown fat.
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Table 1 shows that there was not a decrease in the activity of liver enzymes in the mitochondria, but there was an increase in succinate dehydrogenase.
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I also remember when a tabloid published a phony research paper about the bad effects of the drug Doxylamine Succinate, which was very helpful in treating morning sickness in pregnant women.
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The methylprednisolone sodium succinate (Solu-Medrol) used to treat asthma is safe and unrelated to the contaminated drug.
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Mitochondria from mev-1 animals have decreased complex II-dependent oxidative phosphorylation rates (succinate as the substrate) and decreased complex II activity in ETC studies.
Academic text (2017)
Surface Forms
Morphology
succinate = succinic (semi-transparent) = succin + ate
The formation is a regular chemical derivation ('succinic' + '-ate' = salt/anion), but it requires domain-specific knowledge of 'succinic acid' which many learners lack.
Etymology
Succinate comes from succinic acid, and that name comes from the Latin succinum, which means 'amber' because the acid was first made from amber. The ending -ate means 'salt or ester', so succinate is a 'salt or ester' of succinic acid, which is why you hear it in chemistry and biology when people talk about this molecule.