rofecoxib
1
9.5
- noun
- /ˌroʊfəˈkɒksɪb/
- Specialized
:
rofecoxib
- The newer cyclo-oxygenase-2 inhibitors (e.g., celecoxib and rofecoxib) fall into category C and should be avoided.
- rofecoxib or celecoxib
Examples
-
If necessary, I switch to ibuprofen at 20 mg/kg every 8 hours, diclofenac at 2 to 3 mg/kg twice a day, or rofecoxib at 25 to 50 mg/day.
Academic text (2004) -
By that time, so many patients had been exposed to those drugs that as many as 140,000 excess cases of serious coronary disease might have been caused in the United States by rofecoxib alone.
Academic text (2011) -
The two FDA-approved COX-2 inhibitors on the market today are celecoxib and rofecoxib.
Academic text (2002) -
In 2004, as firms tried to shift even farther to the left by recommending cyclooxygenase-2 drugs for the prevention of colon polyps and other conditions, the inverse benefit (cardiovascular risks) finally became so obvious that rofecoxib was removed from the market.
Academic text (2011) -
Since rofecoxib has a different structure, it's a good alternative to other pain relievers.
-
After its introduction, many patients relied on rofecoxib for effective management of arthritis pain.
-
Due to serious safety concerns, rofecoxib was withdrawn from the market in 2004.
Synonyms
17
9.7
A pain medicine once used to reduce inflammation that was removed from sale for safety reasons
Surface Forms
Etymology
Rofecoxib breaks into parts: the -coxib part comes from COX, short for cyclooxygenase, the enzyme that helps cause 'inflammation' and 'pain', and the first part rof(e)- is a made-up prefix to make the drug name unique. So, the name shows it is a medicine that blocks COX enzymes to reduce 'pain' and 'inflammation'.