proband
1
9.9
- noun
- /ˈproʊbænd/
- Specialized
- The proband was the first family member diagnosed with the rare genetic disorder, initiating the study for potential treatments.
Examples
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Disease onset in the proband was at age 16 months, when she developed a fever, hemolytic anemia, and thrombocytopenia.
Academic text (2003) -
All available siblings of the probands were also enrolled in the study and received the same test battery as the probands.
Academic text (2013) -
Both biological parents of each proband participated, and where available, additional family members also participated.
Academic text (2011) -
In this respect, HF1 concentrations are within normal range in the proband, but above normal in the non-affected father.
Academic text (2003) -
A total of 461 students (probands and siblings) met the criteria and participated in the study.
Academic text (2013) -
Table I shows the HLA A1, B8, and DR3 gene frequencies, comparing the probands to the antibody-screened first-degree relatives.
Academic text (1991) -
In the research, the proband's genetic profile helped scientists understand how the disease was inherited within the family.
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Doctors noted various symptoms in the proband that were crucial for diagnosing the inherited condition affecting the entire family.
Surface Forms
Etymology
Proband comes from the Latin root prob- meaning 'to test' or 'to prove', and it is like the English word probe which means 'to examine'. So, a proband is the person chosen as the first case to test or study when doctors trace a disease in a family.