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ortholog

ortholog

1 9.6
A gene in another species that comes from the same gene in an earlier species and does the same job
  • noun
  • /ˈɔrθəˌlɔg/
  • Specialized
translation icon : ortólogo
  • However, despite extensive database research, no murine ortholog of IL-1F7 has been found.
  • identifying orthologs

Examples

  • The study revealed that the ortholog of a certain gene in zebrafish performs the same role as its counterpart in humans.

  • For each pair, the chromosome location of the C. elegans ortholog was identified.

    Academic text (2017)
  • What are the functions of amh orthologs in fish species?

    Academic text (2017)
  • For all datasets except BIR, orthologs were identified using the Maximum Inclusion method of 51.

    Academic text (2018)
  • Nevertheless, each dataset had at least a few orthologs that passed a strict clock test, even if these orthologs were in the small minority.

    Academic text (2018)
  • We identify that the requirement for HSF-1 in this phenotype was IL2 neuron-specific and required the downstream expression of the a-crystallin ortholog HSP-16.48.

    Academic text (2017)
  • The researchers compared the fruit fly gene to its ortholog in the human genome to understand its functions.

  • By analyzing various species, scientists identified the ortholog of a gene responsible for color vision.

Surface Forms

ortholog singular
orthologs plural

Morphology

ortholog = ortho + log

Formed from Greek combining elements ('ortho-' + '-log') that are technical and not recognizable as standalone English words to an average B1 learner, so the meaning cannot be derived from familiar base words.

Etymology

The word ortholog comes from Greek parts ortho- meaning 'right' or 'straight' and -log meaning 'study' or 'relation', like in orthodox and logic. So an ortholog is the 'right' matching gene in another species that keeps the same job.