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oncogene

oncogene

3 9.5
A gene that can make a normal cell turn into a cancer cell
  • noun
  • /ˈɑŋkəˌdʒin/
  • Specialized
translation icon : oncogén
  • Moreover, EZH2 acts as an oncogene, as it is overexpressed in many solid cancers in both advanced and metastatic diseases.
  • oncogene activation

All the all the so-called oncogenes cancer genes based on percentages, a certain percentage of people with this gene will have you know, the cancer.

Examples

  • With information about which oncogene is causing the cancer to grow, specific therapies can be developed to block that gene.

    Blog text (23)
  • Scientists have identified dozens of oncogenes that stimulate its growth.

    Blog text (23)
  • Different tumors are driven by different oncogenes, different environmental influences, and different biochemistry.

    Blog text (18)
  • Both the activation of oncogenes and the inactivation of tumor suppressor proteins are involved in these pathways.

    Academic text (2003)
  • MEN is caused by a mutation in the RET proto-oncogene, and specific codon mutations within RET correlate with disease phenotype and severity.

    Academic text (2007)
  • An oncogene can trigger uncontrolled growth in a normal cell, leading to cancer.

  • Scientists study how oncogenes can convert healthy cells into cancerous ones.

  • Mutations in oncogenes have the potential to cause significant changes in cell behavior, resulting in cancer.

Synonyms

transforming gene
vsoncogene
  • Specialized
6.5

A gene that makes normal cells turn into cancer cells

tends to cause cancer by promoting uncontrolled cell growth

Compounds

proto-oncogene
  • Specialized
9.7

A normal gene that can change and make cells grow too much, causing cancer

Surface Forms

oncogene singular
oncogenes plural

Morphology

oncogene = gene (semi-transparent) = onco + gene + onco

The base 'gene' is clear to learners, but 'onco' is a specialized combining form (not a standalone word), so the cancer-related meaning is only partially derivable.

Etymology

Oncogene breaks into onco-, which means 'tumor' or 'mass', and gene, the familiar word for a unit that carries traits in living things. So an oncogene is literally a 'tumor gene' — a gene that can make a normal cell grow into cancer.