myelofibrosis
1
9.9
- noun
- /ˌmaɪəloʊfaɪˈbroʊsɪs/
- Specialized
:
mielofibrosis
- Many people living with myelofibrosis experience fatigue and weakness due to a decrease in blood cell production.
Examples
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However, only about half of patients with myelofibrosis were found to have the JAK2 mutation.
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Incyte partnered with Novartis and licensed its myelofibrosis drug Jakavi to treat the rare blood cancer.
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Historically, patients with myelofibrosis have had few treatment options.
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I am a survivor of melanoma, and my mom is facing myelofibrosis, a rare form of cancer.
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Ruxolitinib represents a new class of drugs and a new approach to the treatment of myelofibrosis.
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Moreover, significant improvements in myelofibrosis-related symptoms and quality of life were reported.
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Myelofibrosis is the most serious of the myeloproliferative neoplasms, which are clonal proliferative diseases.
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Remarkably, ruxolitinib significantly down-modulated the high levels of proinflammatory cytokines present in the circulation in myelofibrosis patients.
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The results of this phase I-II study provided the first evidence that ruxolitinib is an effective therapy for myelofibrosis by reducing spleen size and improving myelofibrosis-associated symptoms.
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The findings described in this publication demonstrated that ruxolitinib treatment, by inhibiting JAK1 and JAK2, resulted in significant clinical benefits, including reductions in spleen size and improvements in myelofibrosis symptoms.
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Surface Forms
Morphology
myelofibrosis = fibrosis (opaque) = myelo + fibro + osis
The base 'fibrosis' and the combining form 'myelo-' are both technical medical elements; the combined meaning (scarring of bone marrow) is specialized and not derivable by average learners.
Etymology
Myelofibrosis comes from parts meaning 'marrow' (myelo-) and 'fiber' (fibrosis). So it describes the bone marrow being replaced by scar-like fibers, which is why the marrow cannot make normal blood cells.