methacholine
1
9.9
- noun
- /ˌmɛθəˈkoʊlin/
- Specialized
- Direct bronchial challenge tests with histamine or methacholine in adults and young people older than 16 years should be reserved for cases where there is diagnostic uncertainty after other objective tests.
- methacholine challenge
- methacholine test
- positive methacholine
Examples
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When Kumar and Busse (1995) evaluated athletes at the University of Wisconsin, 2.6% had a reported history of asthma, but an additional 17% had a positive methacholine challenge test for EIA.
Academic text (2004) -
Spirometry and methacholine challenge were carried out, and total and specific IgE were measured.
Academic text (2001) -
Responses to sodium nitroprusside and methacholine in the two study groups were not significantly different.
Academic text (1992) -
Vasodilation in response to methacholine was not significantly reduced in the hypercholesterolemic subjects in our study.
Academic text (1992) -
These investigators used methacholine as a muscarinic agonist and endothelium-dependent vasodilator.
Academic text (1992) -
The diagnosis is based on abnormal findings on pulmonary function testing (i.e., methacholine challenge).
Academic text (2009) -
Methacholine challenge was done with a dosimeter (Mefar, Brescia, Italy).
Academic text (2001) -
It was also determined that while none of the university basketball team had reported asthma on their sport physicals, 25% had a positive methacholine challenge test for EIA.
Academic text (2004) -
Thus, the unexpected findings of Creager et al. might be explained by a difference between the actions of methacholine and acetylcholine, perhaps due to differential actions on muscarinic receptor subtypes.
Academic text (1992) -
Asthma patients often undergo tests involving inhaled methacholine, a drug that can cause narrowing of the airways, similar to what occurs in asthma.
Synonyms
A drug that makes glands produce more liquid and makes muscles inside organs move more
Surface Forms
Morphology
Etymology
Methacholine combines meth- (a small chemical 'methyl' part) and choline, a body chemical whose name comes from the Greek word for 'bile' and which you can also see in cholesterol. So methacholine is a lab-made version of a natural chemical that acts on nerves and muscles, which is why doctors use it to test breathing.