metalloenzyme
- noun
- /məˈtæl.oʊ.ɪnˌzaɪm/
- Specialized
:
metaloenzima
- Using rather simple models of enzymatic systems, quantum-mechanical calculations have already led to new insights regarding the behavior of electrons during metalloenzyme reaction processes.
- metalloenzyme systems
Examples
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However, we recognize that these simple models do not describe real metalloenzyme systems, including their entire protein environment.
Academic text (2001) -
Although the ONIOM method has not yet been used for the study of metalloenzyme systems, in Section 4 we briefly discuss its applicability to more realistic models of enzymatic reactions.
Academic text (2001) -
Thus, a three-layered ONIOM (MO:MO:MM) method provides an interesting option for metalloenzyme systems.
Academic text (2001) -
We describe the limitations of these models and indicate how they may be further improved to reliably model the reactivities of complicated metalloenzymes.
Academic text (2001) -
The electronic structure theory used in the above calculations for models of metalloenzyme systems is a density functional theory (DFT) method with the B3LYP functional.
Academic text (2001) -
Even with the development of ONIOM or other new tools for the study of large molecular systems, including metalloenzymes, the demand for computational power for modeling biological systems using realistic models is extremely high.
Academic text (2001) -
In the first part of this paper, we review our recent electronic structure studies using relatively simple models of two metalloenzymes: methane monooxygenase and ribonucleotide reductase.
Academic text (2001) -
In computationally studying large realistic models of metalloenzyme systems, one obviously wishes to maintain accuracy equivalent to or even better than that adopted for the small model systems—a good DFT method or, better, a coupled cluster method with a large basis set.
Academic text (2001) -
The ONIOM method developed above appears to be ideally suited for the study of metalloenzyme systems as well as large molecular structures (nanostructures, fullerenes) and realistic catalytic systems (homogeneous, heterogeneous).
Academic text (2001) -
Many metalloenzymes rely on metal ions, such as zinc or copper, to perform essential biochemical reactions.
How Complex
Surface Forms
Morphology
Etymology
Metalloenzyme combines metallo- meaning 'metal' and enzyme meaning a natural 'helper' that speeds up chemical reactions, often using a metal like zinc or iron. So, a metalloenzyme is an enzyme that needs a metal to work.
