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Glite Dictionary
isoform

isoform

2 9.1
A slightly different version of a protein made from the same gene that works in a similar way
  • noun
  • /ˈaɪsoʊfɔrm/
  • Specialized
translation icon : isoforma
  • And again that for these myotonias, these mutations are in the skeletal isoform of the sodium channel.
  • different isoforms
  • two isoforms
  • splice isoform

Now today we realize that there's a clear stratification of risk when it comes to Alzheimer's disease that tracks with those isoforms.

Examples

  • The finding that FST 315 is the predominant circulating FST isoform in human serum supports this concept.

    Blog text (1)

  • The expression of each isoform was greater in GTM in comparison to NTM cells (P < 0.05).

    Blog text (1)

  • Are there any questions about the idea of isoform quantitation?

  • TGF-2 is the most abundant TGF- isoform in the eye. 7, 8

    Blog text (1)

  • There are at least two isoforms of this enzyme; the best characterized form is found in the collecting duct.

    Academic text (1996)

  • We next wanted to assess the expression of specific FST isoforms in TM tissues.

    Blog text (1)

  • We therefore decided to treat neuronal cell lines expressing different Beclin 1 isoforms with Staurosporine.

    Academic text (2018)

  • Antibodies against functionally active isoforms represent a further logical approach to therapeutic modulation.

    Blog text (17)

  • In addition, FST isoforms, FST 288 and FST 315, are present in human NTM and GTM tissues.

    Blog text (1)

  • Research indicates that different isoforms of the same protein can perform similar but not identical functions in the body.

Synonyms

variation
vsisoform
77 3.3

A different form of something, like a design or recipe

is specific to proteins from the same gene with slight structure change but similar function
variant
vsisoform
53 4.9

A different form of something, like a virus or recipe

is specific to proteins from the same gene with slight structure change but similar function

Surface Forms

isoform singular
isoforms plural

Morphology

isoform = form (semi-transparent) = iso + form

The combining form 'iso-' is technical and used in scientific vocabulary; while 'form' is clear, the precise biological sense ('variant of the same protein') requires domain knowledge.

Etymology

Isoform comes from iso- and form, where iso- means 'equal' and form means 'shape' or 'type', the same form you see in the word uniform. So an isoform is like a 'same-type' version of a protein or molecule: it comes from the same gene and works in a similar way but with small differences.