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endothelin

endothelin

9.8
A protein made by cells that makes blood vessels narrow and raises blood pressure
  • noun
  • /ˌɛndəˈθiːlɪn/
  • Specialized
translation icon : endotelina
  • Doctors often measure endothelin levels to assess the risk of hypertension in their patients.
  • plasma endothelin
  • endothelin concentration
  • endothelin release

Examples

  • Whether the lack of increase in plasma endothelin in patients with autonomic failure contributes to their orthostatic hypotension remains to be defined.

    Academic text (1991)
  • Needless to say, the possibility that patients with autonomic failure clear plasma endothelin more rapidly than do normal individuals cannot be excluded from our data.

    Academic text (1991)
  • In normal subjects, upright tilt did not change arterial pressure and significantly increased the plasma concentrations of endothelin and vasopressin.

    Academic text (1991)
  • In subjects with vasovagal syncope, arterial pressure dropped and the plasma concentrations of endothelin and vasopressin rose.

    Academic text (1991)
  • In patients with autonomic failure, upright tilt induced a considerable fall in arterial pressure, no rise in plasma endothelin, and a slight increase in plasma vasopressin.

    Academic text (1991)
  • Plasma concentration of endothelin was determined by radioimmunoassay employing anti-endothelin-1 antiserum, 125I-endothelin-1, and endothelin-1 standards (Peninsula Labs, Belmont, California, USA).

    Academic text (1991)
  • The finding (n3) that in normal subjects plasma concentration of endothelin increased with upright posture and decreased during volume expansion raises the possibility that endothelin is a circulating hormone involved in arterial pressure control.

    Academic text (1991)
  • Increased levels of endothelin can lead to higher blood pressure in patients with cardiovascular conditions.

  • Research shows that endothelin plays a significant role in the regulation of vascular tone.

Antonyms

vasodilator
  • Specialized
1 7.2

A drug that makes blood vessels wider to increase blood flow

Surface Forms

endothelin singular
endothelins plural

Morphology

endothelin = endothelium (semi-transparent) = endothelium + in

Formally built from 'endothelium' + '-in' (a protein-naming suffix); this is predictable to readers familiar with biomedical naming but not to average B1 learners.

Etymology

The word endothelin comes from endo- meaning 'inside' and endothelium, the 'lining' of blood vessels, with the protein ending -in. So endothelin is a protein made by the vessel's inner lining that makes vessels narrow and can raise blood pressure.