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disulfide

disulfide

2 6.6
A bond where two sulfur atoms join in a molecule, for example in proteins
  • noun
  • /daɪˈsʌlfaɪd/
  • Specialized
translation icon : disulfuro
  • Generally, the SF molecule consists of a heavy chain of 390 kDa connected to a light chain of 26 kDa via a disulfide bond.
  • carbon disulfide

Now DTT is a commonly used reducing agent which can reduce disulfide bridges in proteins.

Examples

  • Alpha-lipoic acid (LA) is an eight-carbon endogenous cofactor with a disulfide structure.

    Blog text (23)
  • Keratin proteins are tough, insoluble compounds, which are composed of a tight network of disulfide bonds, courtesy of their high thiol content.

    Academic text (2018)
  • During this process, the keratin molecules are reinforced by the formation of several disulfide bonds.

    Academic text (1995)
  • The major structural change in oxidized HSA is a disulfide-bonded cysteine at the thiol of Cys34 of reduced HAS 88.

    Academic text (2017)
  • During this process, the keratin molecules are reinforced by the formation of several disulfide bonds.

  • Keratin proteins are tough, insoluble compounds, which are composed of a tight network of disulfide bonds, courtesy of their high thiol content.

  • Initially, researchers thought the bond might be a disulfide bridge, a link between two sulfur atoms.

Compounds

carbon disulfide
  • Specialized
6.9

A poisonous clear liquid that easily catches fire and dissolves rubber used to make rayon and cellophane

iron disulfide
  • Specialized
7.4

A mineral made from iron and sulfur that is often called fool's gold

Surface Forms

disulfide singular
disulfides plural

Morphology

disulfide = sulfide (transparent) = di + sulfide

Formed by the chemical prefix 'di-' (two) + 'sulfide', clearly indicating 'two sulfur units/ a bond joining two sulfide groups' in standard chemical nomenclature.

Etymology

Disulfide comes from di- meaning 'two' and sulfide from sulfur, the element that often smells like rotten eggs. So a disulfide is a compound or bond where two sulfur atoms are joined, which is why disulfide links help hold a protein's shape.