demyelination
1
9.9
- noun
- /ˌdɛmɪˌaɪəˈleɪʃən/
- Specialized
- We have shown that demyelination is associated with cerebrospinal fluid S-adenosylmethionine deficiency and that restoration of S-adenosylmethionine is associated with remyelination.
- demyelination with axon sparing
- mechanisms of demyelination
- demyelination is associated with
Examples
-
Thus, S-adenosylmethionine deficiency seems to be critical in the development of the demyelination of these disorders.
Academic text (1991) -
Lilly carried both of the defective genes for M.S., and her MRI showed distinct plaques of demyelination in the spinal cord and brain stem.
Fiction book (1997) -
It attacks their own myelin and leads to the demyelination of the nerves.
-
The mechanism of the demyelination is unknown, but the methyl-transfer pathway has been implicated.
Academic text (1991) -
We found that all five segments exhibited moderate to severe demyelination with axonal sparing.
Academic text (2002) -
The major lesions were foci of perivascular demyelination throughout the cerebral white matter.
Academic text (1991) -
Active demyelination was indicated by the association of fragmented myelinated axons with spongy phagocytes (Figure 2, B).
Academic text (2002) -
We have previously shown that in reductase deficiency, low concentrations of methionine and S-adenosylmethionine were associated with demyelination and that treatment corrects these abnormalities.
Academic text (1991) -
Long-term deficiency of the vitamins cobalamin or folate can cause demyelination of the spinal cord and brain; the appearance of which is called subacute combined degeneration.
Academic text (1991) -
The loss of the myelin sheath is called demyelination, which can severely impair nerve function.
Antonyms
Surface Forms
Morphology
demyelination = myelination (transparent) = de + myelin + ation
For someone who knows 'myelination', adding 'de-' straightforwardly signals removal or loss of that myelinated state.
Etymology
Demyelination combines de- meaning 'remove' and myelin meaning 'marrow' or the soft coating around nerves. So demyelination is the process of 'losing the myelin', like removing the insulation from a wire, which explains why it makes nerve signals weak.