azole

Examples

• All

• Use: usually the IV drug of choice in life-threatening systemic infections or with patients who are immunosuppressed until a response is seen, and then replaced for long-term therapy with an oral azole antifungal.

  Academic text (2005)

• The azoles will also affect mammalian P450 enzymes to some extent.

  Academic text (2005)

• Unfortunately, some strains of C. albicans show resistance to all of the existing azoles.

  Academic text (2000)

• The systemic azoles all differ to some degree in drug-drug interactions, adverse reactions, and clinical application.

  Academic text (2005)

• Ketoconazole (Nizoral) was the first azole antifungal introduced in 1981. It is available today for topical, oral, and vaginal applications.

  Academic text (2005)

• AIDS, directly observed therapy, antiretroviral and azole use, gastrointestinal symptoms, and non-compliance were all associated with ADR in the univariate analysis (Table 3).

  Academic text (1999)

• Allergic fungal otitis also exists, and it may require desensitization immunotherapy, debridement, and azole-derivative systemic therapy to cure.

  Academic text (2005)

• However, all azoles have the potential to inhibit the metabolism of many concurrently administered drugs, which significantly expands the possibility of increased serum levels and toxicity.

  Academic text (2005)

• The incidence of rhabdomyolysis increases dramatically when statins are co-administered with drugs that inhibit their hepatic transformation, such as cyclosporine or azoles.

  Academic text (2007)

• The doctor prescribed an azole to help treat the fungal infection effectively.

Surface Forms

Morphology

Etymology