shikonin

Examples

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• Studies suggest that shikonin may reduce tumor growth in cancer models, making it a focus of ongoing research.

• The lethal effect of shikonin on cancer cells was reported to be associated with RIP1 and RIP3. We thus examined shikonin-induced changes in the protein levels of RIP1 and RIP3 by using western blotting.

  Academic text (2016)

• Additionally, shikonin could also cause DNA damage and inhibit DNA synthesis 17,18.

  Academic text (2016)

• Moreover, the average weight of gliomas reduced significantly after 7 days of treatment with Shikonin (Fig. 5 C).

  Academic text (2016)

• Similarly, shikonin induced a significant reduction in the viabilities of both SHG-44 and U251 cells.

  Academic text (2016)

• After siRNA transfection overnight, the cells were incubated with shikonin at the indicated dose for subsequent experiments.

  Academic text (2016)

• Shikonin is a natural ROS inducer in vitro and in vivo 36.

  Academic text (2016)

• In this study, we found that shikonin upregulated the expression of -H2AX and phosphor-ATM in vitro and in vivo.

  Academic text (2016)

• Moreover, the neutral comet assay demonstrated that glioma cells treated with shikonin had a longer comet tail with increased DNA content.

  Academic text (2016)

• As shown in Fig. 5 A and B, the average volume of xenograft gliomas became markedly smaller in the shikonin group than in the control group at day 4, which continued to day 8 when the mice were sacrificed.

  Academic text (2016)

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