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Glite Dictionary
reductase

reductase

1 8.4
An enzyme that helps a chemical gain electrons in a reaction
  • noun
  • /rɪˈdʌk.teɪs/
  • Specialized
translation icon : reductasa
  • The enzyme 5-alpha-reductase is essential for converting testosterone into dihydrotestosterone.
  • HMG-CoA reductase
  • reductase inhibitors
  • CoA reductase

What might you expect to happen to the normal HMG Co A reductase levels or activities?

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Examples

  • Therefore, any therapy, such as HMG-CoA reductase inhibitors, that may further decrease CoQ10, especially in cardiac patients, is of concern to health care practitioners.

    Academic text (2007)

  • So how about HMG Co A reductase inhibitors?

  • The finding that neither HMG-CoA reductase inhibitor reduced CoQ10 concentrations was not expected.

    Academic text (2007)

  • There are currently six 3-hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) commercially available.

    Blog text (19)

  • Aims: To determine the effect of two different HMG-CoA reductase inhibitors, Simvastatin and atorvastatin, on CoQ10 levels in a randomized crossover fashion.

    Academic text (2007)

  • There have also been reported cases of rhabdomyolysis as a result of interaction between HMG CoA-reductase inhibitors (e.g., statins) and fusidic acid.

    Academic text (2007)

  • Atorvastatin was chosen on the basis of its lipophilicity and because it is the most potent HMG-CoA reductase that theoretically may have the greatest effect on reducing mevalonate and CoQ10 among the reductase inhibitors.

    Academic text (2007)

  • Ribonucleotide reductase is crucial for providing DNA precursors that allow cancer cells to multiply quickly.

  • In the human body, HMG-CoA reductase plays a vital role in cholesterol synthesis.

Synonyms

oxidoreductase
vsreductase
  • Specialized
9.9

A molecule in living cells that helps one chemical give electrons to another

only catalyzes addition of electrons to one specific substance during reaction

Compounds

5-hydroxy-3-methylglutaryl-coenzyme A reductase
  • Specialized
9.9

An enzyme in the liver that helps make cholesterol

HMG-CoA reductase
  • Specialized
7.8

A liver enzyme that helps the body make cholesterol

Surface Forms

reductase singular
reductases plural

Morphology

reductase = reduce (semi-transparent) = reduct + ase

The verb 'reduce' supplies the semantic core, but the suffix '-ase' is a technical biochemical marker for enzymes, so the meaning is predictable mainly to learners familiar with enzyme naming conventions.

Etymology

Reductase comes from reduce (to 'make smaller' or 'bring down') plus the enzyme ending -ase, as in lactase. So a reductase is an enzyme that helps 'reduce' a molecule in a chemical reaction, which is why it changes or lowers that substance in the body.