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preclinical

preclinical

7.2
An early stage of a disease before symptoms appear
  • adjective
  • /priˈklɪnɪkəl/
  • Specialized
translation icon : preclínico
  • "A preclinical, live-animal diagnostic test will allow us to eventually eradicate this disease in the United States and allow us new export opportunities," says ASI's Rodgers.
  • preclinical detection

Examples

  • Some researchers are focusing on identifying biomarkers during the preclinical phase of Alzheimer's disease when symptoms have not yet appeared.

  • Neuroblastoma has several features that at first glance suggest that preclinical detection would reduce mortality.

    Academic text (1996)
  • Neuroblastoma has many characteristics that suggest that preclinical detection might improve outcomes.

    Academic text (1996)
  • Although reliable diagnostic criteria for early or preclinical stages of dementia are not available to date, successful intervention is dependent on early diagnosis (Jorm, 1991).

    Academic text (1996)
  • However, no concomitant decrease was noted in the more advanced stages 3 and 4, as would have been expected had preclinical detection of neuroblastoma reduced the incidence of late-stage disease.

    Academic text (1996)
  • Both were mentored and supervised in their preclinical and clinical teaching experiences by strong, knowledgeable teachers who deepened (and tested) their understandings.

    Academic text (2013)
  • How to design a problem-based curriculum for preclinical years. New York, NY: Springer. Barrows, H. S., & Tamblyn, R. (1980).

    Academic text (2018)
  • However, several methodological limitations, including lack of well-documented and well-controlled population-based studies with adequate ascertainment, preclude a conclusion that preclinical detection of this disease will reduce mortality.

    Academic text (1996)
  • Understanding the preclinical stage of diseases can help develop better treatment strategies before the onset of symptoms.

  • Monitoring changes during the preclinical stage of a condition can lead to earlier interventions and improved patient outcomes.

Synonyms

subclinical
vspreclinical
  • Specialized
1 8.1

A condition without noticeable symptoms yet

is the specific early phase when accurate diagnosis is not possible
prepatent
vspreclinical
  • Specialized
9.9

A disease stage before it can be found by usual tests

is about an early symptomless stage preventing accurate diagnosis
presymptomatic
vspreclinical
  • Specialized
8.1

Before symptoms appear, a person can still spread a disease

is about an early stage where diagnosis is usually not possible

Compounds

preclinical phase
  • Specialized
6.0

A research stage when scientists test a new drug or device in labs and animals before testing in people

preclinical test
  • Specialized
5.6

A lab test on animals to check a new drug or device before human trials

preclinical trial
  • Specialized
6.0

A study on animals to see if a new drug works before testing in people

How Advanced

advanced
65 5.1
clinical
  • Specialized
196 4.2
prodromal
  • Specialized
1 9.9
preclinical
  • Specialized
7.2
incubation period
  • Specialized
8 3.5

Surface Forms

preclinical positive

Morphology

preclinical = clinical (transparent) = pre + clinic + al

The meaning is directly 'before the clinical stage', which is a standard and easily interpretable use of the prefix 'pre-'.

Etymology

Preclinical combines pre- ('before') and clinical ('clinic', a place where patients are seen and treated). So, preclinical describes the time 'before' a disease reaches the clinic or shows clear symptoms.