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Glite Dictionary
🧬 Too much protein 😲 Too much emotion
overexpression

overexpression

2 7.7
Making much more of a protein or gene product than normal inside a cell
  • noun
  • /ˌoʊvərˈɛkspresʃən/
  • Specialized
translation icon : sobreactuación
  • IFITM1 overexpression also improved breast cancer cell survival and aggression under estrogen-deprived conditions.
  • p53 overexpression
  • bcl-2 overexpression
  • SLeX overexpression

We got the whole yeast sirtuin situation, which is at least in some yeast sirtuin overexpression lives longer.

Examples

  • Significantly, in this study, overexpression of IFITM1 promoted MCF-7 cell survival in estrogen-deprived conditions.

    Academic text (2017)

  • Pancreatic ductal adenocarcinoma (PDAC) is another tumor entity characterized by the overexpression of several miRNAs, miR-21 inclusive.

    Academic text (2016)

  • Further experiments are needed to study whether ACE overexpression in human myeloid cells has effects similar to those in mice.

    Academic text (2018)

  • In conclusion, this study demonstrated that IFITM1 overexpression promotes AI-resistant breast cancer cell aggression and survival.

    Academic text (2017)

  • In this study, we observed p53 overexpression in normal-looking or dysplastic mucosa in four cases.

    Academic text (1995)

  • Our study demonstrated overexpression of EphB4 in primary HNSCC and cervical lymph node metastases.

    Academic text (2003)

  • In vivo studies using the orthotopic and MIND models of breast cancer reveal that IFITM1 overexpression enhances tumor progression and invasion.

    Academic text (2017)

  • In this experiment, the overexpression of the insulin gene led to increased insulin levels in the modified cells.

  • Researchers noted the overexpression of the BRCA1 gene in certain breast cancer patients, which may influence treatment options.

  • The study found that overexpression of the VEGF protein played a crucial role in tumor growth and angiogenesis.

Synonyms

superexpression
vsoverexpression
  • Specialized
9.9

An unusually high gene activity that makes large amounts of a protein

has identical meaning but uses a different term form

Antonyms

underproduction
6.1

Making less than is needed or expected

How Active

superexpression
  • Specialized
9.9
overexpression
  • Specialized
2 7.7
gene expression
  • Specialized
5 4.3

Surface Forms

overexpression singular
overexpressions plural

Morphology

overexpression = expression (transparent) = over + express + ion

Although technical, the sense is compositionally 'over' (excessive/high) + 'expression' (production), so the relation is clear.

Etymology

Overexpression in biology uses the same parts: over- 'too much' and expression 'making' or 'showing' what a gene does, so it means a gene or cell is making 'too much' of a protein, which can lead to problems.